T-cell effector functions and the MHC

Question 1

MHC class I
a. is an αβ heterodimer
b. is expressed on all nucleated cells
c. is only expressed on antigen-presenting cells
d. binds to CD4 receptors
e. is a membrane-associated protein

Answer 1

B

Question 2

Exogenous antigen
a. are only presented on MHC class II on antigen-presenting cells
b. are presented on MHC class I or II on antigen-presenting cells
c. are presented on MHC class II on all cells
d. are only presented on MHC class I on antigen-presenting cells
e. are presented on MHC class I on all cells

Answer 2

A

Question 3

The variability of the MHC is located structurally in
a. all parts of the molecule
b. the stalk only
c. the intracellular domain only
d. the part of the MHC holding antigen only
e. the α subunits only

Answer 3

D

Question 4

The genes encoding the MHC are
a. A, B, C
b. V, D, J
c. V, J
d. α, β, δ, γ
e. V, D, J, C

Answer 4

A

not B!!!

Question 5

The TCR usually consists of the domains a. αC, βC, αV, βV
b. α1, α2, α3, β
c. HC, HV, LC, LC
d. α, β, δ, γ
e. V, D, J, C

Answer 5

a

Question 6

Which molecules are linked?
a. CD4, MHC I, exogenous antigen
b. CD8, MHC II, exogenous antigen
c. CD8, MHC I, endogenous antigen
d. CD8, MHC I, exogenous antigen
e. CD4, MHC II, endogenous antigen

Answer 6

c

Question 7

A T cell is activated when
a. CD4 or CD8 binds to the T-cell receptor
b. CD28 binds to CD86
c. CD4 or CD8, the T-cell receptor, and MHC bind together
d. CD4 or CD8, the T-cell receptor, and MHC bind, and CD28 binds to CD86
e. The T-cell receptor binds to MHC, and CD28 binds to CD86

Answer 7

D

Question 8

When a T cell is activated by a virally-infected cell, the T cell
a. kills the virus without killing the cell
b. causes the cell to die by necrosis
c. marks the cell for phagocytosis
d. causes the cell to die by apoptosis
e. inactivates the virus without killing the cell

Answer 8

D

viruses cannot be killed without affecting cell/host so it undergoes apoptosis (programmed cell death)

Question 9

Match the T cell to the cytokines it secretes.

a. CD4+ Th1
b. CD4+ Th2
c. CD4+ Th17
d. CD4+ Treg

i. Il-17, Il-21
ii. IFN-γ, Il-2
iii. Il-4, Il-13
iv. TGF-β, Il-10

Answer 9

a. ii.
b. iii.
c. i.
d. iv.

Question 10

Match the T cell to its main role.
a. CD4+ Th1
b. CD4+ Th2
c. CD4+ Th17
d. CD4+ Treg

i. providing help to B cells
ii. inhibiting the immune response
iii. targeting intracellular pathogens
iv. targeting extracellular bacteria & fungi

Answer 10

a. iii.
b. i.
c. iv.
d. ii.

Question 11

CD4+ Th1 activates

a. CD8+ via Il-2 only
b. macrophages via Il-2 only
c. CD8+ via IFN-γ only
d. macrophages via IFN-γ & Il-2
e. CD8+ via IFN-γ & Il-2

Answer 11

e

Question 12

CD4+ Th17 cells activate
a. macrophages
b. neutrophils
c. eosinophils
d. mast cells
e. B cells

Answer 12

b

Question 13

CD4+ Tregs
a. stimulate antibody production
b. cause anergy of self-reactive T cells
c. induce apoptosis of self-reactive T cells
d. inhibit the immune response
e. incude apoptosis of self-reactive antibody-secreting cells

Answer 13

d