Antibody, lymphocytes, and the generation of diversity Flashcards
alistair question booklet theme 7
The main cells of the adaptive immune system are
a. granulocytes
b. phagocytes
c. lymphocytes
d. thrombocytes
e. monocytes
c
Creation of diversity in antigen-recognition receptors occurs in
a. T cells only
b. B cells only
c. all lymphocytes
d. NK cells only
e. T cells and B cells
e
T cells
a. secrete antibodies
b. use antibodies as receptors
c. coordinate the immune response
d. are all cytotoxic
e. mature in the thyroid
c
B cells
a. secrete large quantities of a single type of antibody
b. use antibody as a receptor
c. recognise antigen only if presented by antigen-presenting cells
d. ingest pathogens by phagocytosis
e. mature in the blood
b
Antibody specificity varies due to differences in
a. heavy chain sequence
b. antibody class
c. light chain sequence
d. VH and VL sequences
e. α and β chain sequences
d
T-cell receptors
a. consist of 2 heavy and 2 light chains
b. consist of 1 heavy and 1 light chain
c. recognise whole pathogen
d. consist of αβ or γδ chains
e. present antigen
d
Absence of recombination activity in receptor formation in the adaptive immune system causes
a. leukaemia
b. HIV
c. lymphoma
d. autoimmune disease
e. SCID
e
One B cell expresses
a. a random variety of antibody sequences
b. every possible antibody sequence
c. every possible non-self antibody sequence
d. antibodies of a single randomly-determined sequence
e. antibodies of every possible sequence specific to a single pathogen
d
Affinity matching occurs for
a. all T cells
b. all non-self B-cells
c. all non-self T-cells
d. B-cells that bind antigen
e. T-cells that bind antigen
d
Affinity maturation occurs in
a. the thymus
b. the bone marrow
c. B cell follicles
d. T cell follicles
e. affinity nodes
c
Function of antibody is determined by
a. the light chain
b. the variable region
c. the heavy chain
d. the constant region
e. the hypervariable region
d
The part of the gene coding for the constant region is
a. C
b. V
c. D
d. J
e. K
a
IgM is effective at
a. activating complement
b. diffusing into tissue
c. diffusing across the placenta
d. opsonisation
e. antibody-dependent cellular cytotoxicity
a
IgE is important in
a. parasitic infection
b. protection of skin surfaces
c. protection of mucosal surfaces d. Gram-negative infection
e. Gram-positive infection
a
Activation-induced cytidine deaminase
a. repairs DNA damage
b. is necessary for class-switching of T cells c. causes affinity maturation of B and T cells
d. is active in a germinal centre
e. causes deactivation of non-self B cells
d
