T-Cell Development Flashcards
When cells arrive at the thymus what are they and what can they become?
What receptor commits them to T cell lineage?
Where do precursor T-cell migrate to in the thymus?
Give the following
1. four stages of t-cell development
2. location
3. description
4. phenotype
What TCRs can T-cells express and which is more likely?
Draw an overview of the steps for T cell development for DN1 to SP
In what steps does T-cell development undergo B-selection and what does this cause?
What occurs after B/A-selection?
What is positive and negative selection?
Which is failed most?
What presents self-antigens to T-cells undergoing +/- selection?
What is AIRE
What can happen to T-cells that fail negative selection?
What is the selection paradox?
What alternative model can explain the thymic selection paradox.
Do positive/negative election occur at the same stage of development or in sequence?
What are the models proposed to explain lineage commitment?
- Instructive model
- Stochastic model
- Kinetic signaling model
What is the instructive model in lineage commitment?
What is the Stochastic model in lineage commitment?
What is the kinetic signaling model in lineage commitment?
Can DP thymocytes commit to other types of lymphocytes?
If so, what are they?
How does final maturation occur and how do T cell exit the thymus?
What is Treg?
Does tolerance happen anywhere else for t cells
