T Cell activation and generation of effector T cells

Question 1

What do CD8 cells do after detecting peptide on MHC molecule?

Answer 1

Release granzymes to kill infected cells

Question 2

How do antigens enter lymph nodes?

Answer 2

APC (usually dendritic cell) pick up antigen from infected site and travel to lymph node.

Question 3

What happen to T cells once released into lymph nodes?

Answer 3

Patrol node to node and if dendritic cell is present with target antigen, T cell binds and becomes activated

Question 4

What happen to T cells once activated?

Answer 4

T cells move through circulation to infection site depending on chemokines from infection site

Question 5

Where are naiive T cell activated?

Answer 5

secondary lyphoid organs (spleen and lymph nodes) and become effector T cells

Question 6

Which cells present antigens t activate T cells in the lymphoid organs? and why

Answer 6

PROFESSIONAL ANTIGEN PRESENTING CELLS since they express high levels of MHC class 2 and also express co-stimulatory molecules!!!

Question 7

What are the 3 signals for naive t cell activation?

Answer 7

signal 1 - antigen recongition (via TCR and MHC complex)
signal 2 - costimulation
signal 3 - cytokines

Question 8

Which of the three signals initiate an immune response?

Answer 8

signal 1 - antigen recongition

Question 9

Where are co-ctimulatory signals?

Answer 9

Mostly on dendritic cells, may also be on macrophages or B cells

Question 10

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