Autoimmunity Flashcards
Name a few organ specific autoimmune disease? and what the antibodies target for each one?
Graves disease - specifically on TSH receptors in thryroid (stimulatory antibody causies overproduction causing bulging eyes (eye expresses loads of TSH receptors)
Type 1 diaetes - antibodies against insulin producing cells causing insulin producing cell destruction in pancrease so no insulin produced
What is spondylo…
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What is autoimmunity?
Define immune tolerance?
What are the two types of immune tolerance?
How do B cells contribute to central tolerance?
How do T cell contribute to central tolerance?
What do B cells produce?
What are auto-antibodies?
What does rhermutoid factor cause?
How are t cells selected for in the thymus?
What factors are considered when selecting T cells in thymus?
What happens if there are mutations in AIRE?
What is the purpose of AIRE?
What 3 things can happens to cells that have peripheral tolerance?
Where does ignorance take place and why?
anergy
Regu;ation
What do Treg cells do?
What does treg express
What happens if FOXP3 mutates?
What endocrine factors contibute to autoimmunity?
What environmenta factors contibute to autoimmunity?
