Autoimmunity

Question 1

Name a few organ specific autoimmune disease? and what the antibodies target for each one?

Answer 1

Graves disease - specifically on TSH receptors in thryroid (stimulatory antibody causies overproduction causing bulging eyes (eye expresses loads of TSH receptors)
Type 1 diaetes - antibodies against insulin producing cells causing insulin producing cell destruction in pancrease so no insulin produced

Question 2

What is spondylo…

Question 3

…… slide

Question 4

What is autoimmunity?

Question 5

Define immune tolerance?

Question 6

What are the two types of immune tolerance?

Question 7

How do B cells contribute to central tolerance?

Question 8

How do T cell contribute to central tolerance?

Question 9

What do B cells produce?

Question 10

What are auto-antibodies?

Question 11

What does rhermutoid factor cause?

Question 12

How are t cells selected for in the thymus?

Question 13

What factors are considered when selecting T cells in thymus?

Question 14

What happens if there are mutations in AIRE?

Question 15

What is the purpose of AIRE?

Question 16

What 3 things can happens to cells that have peripheral tolerance?

Question 17

Where does ignorance take place and why?

Question 18

anergy

Question 19

Regu;ation

Question 20

What do Treg cells do?

Question 21

What does treg express

Question 22

What happens if FOXP3 mutates?

Question 23

What endocrine factors contibute to autoimmunity?

Question 24

What environmenta factors contibute to autoimmunity?

Question 25

What is the hygeine hypothesis?

Question 26

What might trigger a breakdown of self tolerance?