Humoral Immunity: antibodies and the life cycle of B cells Flashcards
Structure of antibodies
Difference between secreted vs membrane bound antibodies
What cells are membrane bound antibodies found?
What are immunoglobulins?
Antibodies
What are all the bonds in an antibody?
What is a domain of an antibody?
What is a fragment of an antibody?
What is a Fab fragment and what does it do?
What is a CDR?
What is the purpose of a CDR?
What are the different functions of antibodies?
How do antibpdies work against virus and for toxin neutralisation?
How do antibodies work in opsonisation?
What is an ADCP?
What is an ADCC?
What are the different classes of antibodies?
What are the structural differences between the different antibody classes?
What is the function of antibodies in complement fixing and MAC formation?
When do IgA’s form?
What is the function of class of antibodies?
Which antibody is a first responder and why?
What are the order of antibodies in affinity maturation
Describe the characteristics of IgG?
What is the role of cytokines in antibody classes?
What are the requirements for class switching recombination (CSR)?!!!!
What are the steps in class switch recombination?
How do membrane bound antibodies become secreted antibodies?
Which part of the antibdoy undergoes class switching
Heavy chain
- rest stays the same
What are the steps in life cycle of B cells
When is differenitial splicing used in making antibodies?!!!!!
When is somatic recombination used in antibody formation?
What are the 2 stages of B cell life cycle?
Where does the antigen dependent portion of B cell life cycle occur?
Where does the antigen independent stage of B cell life cycle occur?
How does a B cell become activated?
What steps occur once a B cell is activated
How are so many unique antibodies generated?
What are the segments of genes in light chain ?
What are the segments of genes in heavy chain?
Which genes code of variable region of antibodies vs constant region of antibodies?
How many genetic loci are there to encode Ig?
What are the genetic loci for light chain of antibodies?
What are the genetic loci for heavychain of antibodies?
How many V segments are there?
How many J segments are there?
How many c segments are there?
What happens in VJ recombination?
stuff in the middle needed
