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Microbiology and Immunology > Humoral Immunity: antibodies and the life cycle of B cells > Flashcards

Humoral Immunity: antibodies and the life cycle of B cells Flashcards

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Biology 101 flashcards
1
Q

Structure of antibodies

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2
Q

Difference between secreted vs membrane bound antibodies

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3
Q

What cells are membrane bound antibodies found?

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4
Q

What are immunoglobulins?

A

Antibodies

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5
Q

What are all the bonds in an antibody?

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6
Q

What is a domain of an antibody?

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7
Q

What is a fragment of an antibody?

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8
Q

What is a Fab fragment and what does it do?

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9
Q

What is a CDR?

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10
Q

What is the purpose of a CDR?

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11
Q

What are the different functions of antibodies?

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12
Q

How do antibpdies work against virus and for toxin neutralisation?

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13
Q

How do antibodies work in opsonisation?

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14
Q

What is an ADCP?

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15
Q

What is an ADCC?

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16
Q

What are the different classes of antibodies?

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17
Q

What are the structural differences between the different antibody classes?

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18
Q

What is the function of antibodies in complement fixing and MAC formation?

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19
Q

When do IgA’s form?

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20
Q

What is the function of class of antibodies?

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21
Q

Which antibody is a first responder and why?

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22
Q

What are the order of antibodies in affinity maturation

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23
Q

Describe the characteristics of IgG?

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24
Q

What is the role of cytokines in antibody classes?

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25
Q

What are the requirements for class switching recombination (CSR)?!!!!

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26
Q

What are the steps in class switch recombination?

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27
Q

How do membrane bound antibodies become secreted antibodies?

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28
Q

Which part of the antibdoy undergoes class switching

A

Heavy chain

- rest stays the same

29
Q

What are the steps in life cycle of B cells

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30
Q

When is differenitial splicing used in making antibodies?!!!!!

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31
Q

When is somatic recombination used in antibody formation?

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32
Q

What are the 2 stages of B cell life cycle?

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33
Q

Where does the antigen dependent portion of B cell life cycle occur?

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34
Q

Where does the antigen independent stage of B cell life cycle occur?

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35
Q

How does a B cell become activated?

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36
Q

What steps occur once a B cell is activated

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37
Q

How are so many unique antibodies generated?

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38
Q

What are the segments of genes in light chain ?

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39
Q

What are the segments of genes in heavy chain?

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40
Q

Which genes code of variable region of antibodies vs constant region of antibodies?

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41
Q

How many genetic loci are there to encode Ig?

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42
Q

What are the genetic loci for light chain of antibodies?

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43
Q

What are the genetic loci for heavychain of antibodies?

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44
Q

How many V segments are there?

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45
Q

How many J segments are there?

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46
Q

How many c segments are there?

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47
Q

What happens in VJ recombination?

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48
Q

stuff in the middle needed

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Microbiology and Immunology (31 decks)

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