Systemic Lupus Erythematosus Flashcards
1
Q
Prevalence of SLE
A
Female
15-50 Years
Afro Carribbean in Particular
2
Q
Genetic Factors of SLE
A
Monozygotic Twins in Particular
Sibling risk
Polygenic mode of inheritance
3
Q
Environmental Factors of SLE
A
UV Light
Drugs
Infections
4
Q
Pathogenesis of SLE
A
Immune response against endogenous nuclear antigens
complement activation
tissue injury
5
Q
Clinical presentation of SLE
A
Butterfly Rash Photosensitivity Fever Depression Vasculitis Purpura Urticaria Pleurisy Pleural Effusion Fibrosis Raynauld Septic Necrosis of Hip Arthritis in Small Joints Alopecia Fits Hemiplegia Ataxia Peripheral Neuropathy Cranial Nerve Lesion Pericarditis Endocarditis Abdo Pain Myelopathy Anaemia Leukopenia Thrombocytopenia
6
Q
Classification Criteria of SLE (any 4)
A
Malar Rash (Butterfly Rash) Discoid Rash (Raised/Scar/Perm/Alopecia) Photosensitivity Oral Ulcers Arthritis (2 Joints at Least) Serositis (Pleurisy or Pericarditis) Renal (Cellular Casts or Proteinuria in Urine) Unexplained Seizures Psychosis Low WCC Platelets Haemolytic Anaemia Cardiolipin Lupus Anticoagulant Anti ds dNA Low Complement ANA
7
Q
SLE can cause what to happen to kidneys
A
Lupus Nephritis
8
Q
When to consider diagnosis of SLE
A
Women of childbearing age Fever Weight Loss Malaise and Severe Fatigue Skin Rash Arthritis Pleuritic Chest Pain Renal Disease Cytopenia
9
Q
Which autoantibodies seen in SLE, MCTD and Drug Induced Lupus
A
ANA, Anti ds-DNA
10
Q
Strongest clinical association for Anti ds DNA is with
A
Nephritis related to SLE
11
Q
Which autoantibodies are highly specific for SLE
A
Anti ds DNA and Anti SM
12
Q
Anti RO is related to what
A
Neonatal Lupus
