Paget's disease of Bone

Question 1

What is Paget’s disease of bone

Answer 1

localised disorder of bone turnover

increased bone resorption followed by increased bone formation

Question 2

what does Paget’s disease of bone lead to

Answer 2

bigger less compart, more vascular and more susceptible to deformity and fracture

Question 3

Paget Disease causes

Answer 3

Strong genetic component
15-30% Familial
SQSTMI
Anglo Saxon
Environment Trigger within Osteoclast

Question 4

Paget Disease Symptoms

Answer 4

> 40
Bone Pain
Excessive Heat
Hearing Loss

Question 5

Paget Disease Diagnosis

Answer 5

Isolated elevation of serum alkaline phosphatase

Question 6

Treatment of Paget Disease

Answer 6

Do not treat asymptomatic unless in skull or requiring surgery

Question 7

Do not treat Paget Disease based on

Answer 7

raised alkaline phosphatase alone

Question 8

How could you treat Paget Disease

Answer 8

IV Bisphosphonate Therapy with One off Zoledronic Acid infusion

Question 9

Paget Disease can be effectively managed when required using

Answer 9

IV Bisphosphonates