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Systems Year 2 Rheumatology > Seropositive Rheumatoid Arthritis > Flashcards

Seropositive Rheumatoid Arthritis Flashcards

1
Q

What would you be looking for in Seropositive Rheumatoid Arthritis

A

Anti Citrullinated Protein Antibody (Acpa)

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2
Q

What diagnostic test recognises citrullinated self proteins in Seropositive RA

A

Anti CCP Assays

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3
Q

Name 6 Citrullinated Self Proteins

A 
A-Enolase
Keratin
Fibrinogen
Fibronectin
Collagen
Vimentin
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4
Q

Patients with ACPA+ Disease have what prognosis

A

less favourable

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5
Q

Rheumatoid Factor is an auto antibody to what

A

Self IgG Fc

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6
Q

What infectious agents have been associated with RA

A 
EBV
CMV
E Coli
Mycoplasma
Periodontal Disease
Microbiome
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7
Q

Repeated insults with environmental factors in genetic susceptible to Rheumatoid Arthritis individual would lead to (2)

A

Formation of immune complexes and rheumatoid factor (high-affinity autoAb against the Fc portion of Ig)

Altered citrullination of proteins and breakdown of tolerance, with resulting ACPA response

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8
Q

What mediates systemic effects in RA

A

iL-6

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9
Q

inflammatory cytokines in RA promote

A

angiogenesis

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10
Q

what provides nutrients to hyper plastic synovial in RA

A

Neo-angiogenesis

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11
Q

Bone destruction in RA is mediated by

A

Osteoclasts that are activated by RANKL

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12
Q

What happens to endothelial activation in RA

A

Increased

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13
Q

How does Secondary Fibromyalgia happen in RA

A

Dysregulation of HPA Axis

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14
Q

IL6 in RA increases what

A

hepatocyte production of hepcidin

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15
Q

Which bone condition is linked to RA

A

Osteoporosis

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16
Q

which muscle condition is linked to RA

A

Sarcopenia

17
Q

Evidence of autoimmunity, including high serum levels of autoAb (RFs and anti-CCP), can be present for

A

many years before onset clinical arthritis

18
Q

which cytokine networks involved in RA

A

TNFa

IL6

19
Q

Bone and cartilage destruction are primarily mediated by

A

Osteoclasts

Synoviocytes

Systems Year 2 Rheumatology (30 decks)

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