Systemic Lupus Erythematosis

Question 1

SLE is an ___________ disease

Answer 1

SLE is an AUTOIMMUNE disease

Question 2

name the classification criteria fro SLE

Answer 2

SLICC classification criteria

Question 3

what is increased in SLE?

Answer 3

cell death

Question 4

where do immune complexes form in SLE?

Answer 4

small blood vessels

Question 5

antibody-antigen complexes are deposited on the basement membrane of what?

Answer 5

skin and kidneys

Question 6

in who is SLE common?

Answer 6

female
after puberty
20s/30s

black persons

Question 7

today, mortality in SLE is not due to the disease itself but is due to…

Answer 7

medication side effects such as fatal infections due to immunosuppression or CVS events

Question 8

general SLE presentation/signs/symptoms…

Answer 8

fever
fatigue
weight loss

Question 9

musculoskeletal SLE presentation/signs/symptoms…

Answer 9

arthralgia
myalgia
inflammatory arthritis
arthropathy
avascular necrosis

Question 10

muco-cutaneous SLE SLE presentation/signs/symptoms…

Answer 10

malar rash
photosensitivity
discoid lupus
subacute cutaneous lupus
oral/nasal ulceration
raynauds phenomenon

butterfly rash
alopecia

Question 11

renal SLE presentation/signs/symptoms…

Answer 11

lupus nephritis

Question 12

respiratory SLE presentation/signs/symptoms…

Answer 12

pleurisy
pleural effusion
pneumonitis
pulmonary embolism
pulmonary hypertension
interstitial lung disease

Question 13

haematological SLE presentation/signs/symptoms…

Answer 13

leukopenia
lymphopenia
anaemia
thrombocytopenia

Question 14

cardiac SLE presentation/signs/symptoms…

Answer 14

pericarditis
pleural effusion
pulmonary hypertension
sterile endocarditis
accelerated ischaemic heart disease

Question 15

gastrointestinal SLE presentation/signs/symptoms…

Answer 15

autoimmune hepatitis
pancreatitis
mesenteric vasculitis

Question 16

is there one diagnostic test for lupus?

Answer 16

no

Question 17

name the antibody that is positive but not specific for SLE

Answer 17

anti-nuclear antibody (ANA)

Question 18

name the antibody that is specific for lupus and varies with disease activity

Answer 18

anti-dsDNA

Question 19

name the antibody for SLE that is specific but low sensitivity

Answer 19

anti-Sm

Question 20

name the 3 antibodies that are seen in SLE but may also be seen in other conditions

Answer 20

anti-Ro
anti-La
anti-RNP

Question 21

levels of what are low when SLE is active, especially renal disease

Answer 21

C3/4

Question 22

what are you looking for in urinalysis of those with suspected SLE?

Answer 22

glomerulonephritis

Question 23

name what test is performed to investigate the following complications of SLE:

(a) interstitial lung disease
(b) cerebral vasculitis
(c) pericardial effusion

Answer 23

(a) interstitial lung disease - CT CHEST
(b) cerebral vasculitis - MRI BRAIN
(c) pericardial effusion - ECHO

Question 24

SLE management:

skin disease and arthralgia

Answer 24

hydroxychloroquine
topical steroids
NSAIDs

Question 25

SLE management:

inflammatory arthritis or evidence of some types of organ involvement e.g. pericardial disease or interstitial lung disease

Answer 25

immunosuppression with azathioprine or mycophenolate mofetil

corticosteroids can be used short term

Question 26

SLE management:

severe organ disease e.g. lupus nephritis or CNS lupus

Answer 26

IV steroids and cyclophosphamide

Question 27

SLE management:

unresponsive cases

Answer 27

IV immunoglobulin and rituximab

Question 28

what should be checked regularly in those with SLE?

Answer 28

anti-dsDNA

complement

Question 29

what are you looking for in urine in those with SLE?

Answer 29

blood or protein indicating glomerulonephritis

Question 30

what CVS things should be checked in those with SLE?

Answer 30

BP

cholesterol