Seronegative Inflammatory Arthropathies Flashcards
name the 4 diseases that are seronegative in nature
AS
psoratic arthritis
enteropathic arthritis
reactive arthritis
name the part of the body that is mainly affected in seronegative inflammatory arthropathies
spine - spondyloarthropathy and an asymmetric oligoarthritis
sacroiliitis, uveitis, dactylitis (inflammation of a digit) and enthesopathies are common (especially achilles insertional tendonitis and plantar fasciitis) in seronegative inflammatory arthropathies
true or false?
true
those with seronegative inflammatory arthropathies are usually positive in what?
HLA-B27
what is often elevated in seronegative inflammatory arthropathies?
CRP and ESR
name the chronic inflammatory disease of the spine and sacro‐iliac joints which can lead to eventual fusion of the intervertebral joints and SI joints
ankylosing spondylitis
what sex are more affected by AS?
male aged 20-40
is AS painful?
yes - also stiff
do those with AS have morning stiffness?
yes - improves with exercise
in AS, there is development of a ‘_________ ____’ spine
in AS, there is development of a ‘QUESTION MARK’ spine
in an AS spine, there is ____ of lumbar ________ and ___________ thoracic ________
in an AS spine, there is LOSS of lumbar LORDOSIS and INCREASED thoracic KYPHOSIS
‘L-L-L’
how is lumbar spine flexion measured?
Schobers test
name some associated conditions of AS
anterior uveitis
aortitis
pulmonary fibrosis
amyloidosis
x-ray findings of AS?
sclerosis and fusion of the sacroiliac joints
bony spurs from vertebral bodies - syndesmophytes
‘bamboo spine’
what test can detect earlier features of AS?
MRI - bone marrow oedema and enthesitis of the spinal ligaments
AS treatment?
physiotherapy
exercise
NSAIDs
anti-TNF inhibitors
DMARDs have no impact on spine but good for peripheral joint inflammation
surgery for hip and knee arthritis and kyphoplasty to straighten spine
what affects 30% of people with psoriasis?
psoriatic arthritis
is psoriatic arthritis symmetrical?
no - asymmetrical oligoarthritis but may also affect hands similar to OA
spondylitis, dactylitis and enthesitis commonly occur
state the nail changes in psoriasis
pitting and onycholysis (lifting of nail from bed)
what joint of the finger is commonly affected in psoriatic arthritis?
DIP
name the aggressive and destructive form of the condition seen in 5% of those with psoriatic arthritis
arthritis mutilans
psoriatic arthritis treatment?
similar to RA
DMARDs - methotrexate
anti-TNF
joint replacement in larger joints and joint fusion
name the nflammatory arthritis involving the peripheral joints and sometimes spine, occurring in patients with inflammatory bowel disease (Crohn’s disease and Ulcerative Colitis)
enteropathic arthritis
what joints are affected in enteropathic arthritis?
large joints asymmetrical oligoarthritis
