Systemic Diseases

Question 1

Hypercoagulable State+Increased PTT+Pregnancy?

Answer 1

Think Antiphospholipid syndrome

Question 2

Scleroderma in one phrase?

Answer 2

Deposition of Collagen=>hardening of tissues (sclerosis)

Question 3

Scleroderma usually occurs in which population?

Answer 3

Middle aged female

Question 4

Diffuse scleroderma vs CREST?

Answer 4

Diffuse=>widespread skin involvement, Rapid and early

Question 5

anti-Scl-70 ab is associated with? What kind of ab is SCL-70?

Answer 5

Diffuse Scleroderma (70 is when you have diffuse pain)

Anti-DNA topoisomerase I ab

Question 6

CREST?

Answer 6

Calcinosis,
Raynaud phenomenon,
Esophageal dysmotility,
Sclerodactyly, and Telangiectasia

Question 7

Anti-centromere antibody is associated with?

Answer 7

CREST

Question 8

What happens to LES and peristalsis?

Answer 8

Decreased

Question 9

Scleroderma Pathogenesis?

Answer 9

Increased endothelian, PDGF, Vasoconstriction

Question 10

Osteoarthritis Findings?

Answer 10

eburnation (polished, ivory-like appearance of bone) Heberden nodes (DIP), Bouchard nodes (PIP).

Question 11

Typical presentation of Osteoarthritis

Answer 11

Gets worse throughout the day

Question 12

Cartilage is what kind of a collagen?

Answer 12

Type 2

Question 13

Rheumatoid Factor?

Answer 13

IgM binding to the Fc portion of IgG

Question 14

What are three findings of RA?

Answer 14

Pannus (inflammatory granulation tissue) formation in joints (MCP, PIP), subcutaneous rheumatoid nodules (fibrinoid necrosis), ulnar deviation of fingers

Question 15

In RA, what is spared?

Answer 15

DIP is spared

Question 16

Most specific Ab for RA?

Answer 16

Anti-Cyclic Citrullinated peptide

Question 17

RA has strong associaion with?

Answer 17

HLA DR4 (RHEU)

Question 18

Sjorgen is what kind of HSR?

Answer 18

Type 4 HSR

Question 19

3 presentations of Sjorgen?

Answer 19

Dry Eyes, Dry Mouth, Recurrent Dentals “Can’t chew on cracker and have dirt in my eyes”

Question 20

SSA and SSB are what kind of Ab?

Answer 20

ANA

Question 21

Do Sjorgen patients have Bilateral Parotid Enlargement? What does this lead to?

Answer 21

Increased risk of B-cell lymphoma

Question 22

Does SSA cross the placenta? If it does, what does it cause?

Answer 22

Yes, Congenital Heart Block

Question 23

Lymphocytic sialdenitis is associated with?

Answer 23

Sjorgen

Question 24

Gout is it underexretion or Overproduction?

Answer 24

Underexcretion

Question 25

Why is alcohol a problem?

Answer 25

alcohol metabolites compete for same excretion sites in kidney as uric acid=>decreases uric acid secretion and subsequent buildup in blood

Question 26

Calcium pyrophsophate crystals that form basophilic, rhomboid crystals?

Answer 26

Pseudogout

Question 27

In paraLLel light, how does gout look like?

Answer 27

yeLLow

Question 28

MCC #1 and #2 of Infectious Arthritis?

Answer 28

Neisseria Gonorrhea (young adults) and Staph Aureus (Older adults)

Question 29

migratory arthritis with an asymmetric pattern?

Answer 29

Infectious Arthritis

Question 30

Infectious Arthritis has STDs

Answer 30

Synovitis (e.g., knee), Tenosynovitis (e.g., hand), and Dermatitis

Question 31

PAIR pathologies have a strong association with?

Answer 31

Strong association with HLA-B27 (gene that codes for MHC class I)

Question 32

PAIR occurs more often in?

Answer 32

Males

Question 33

Dactylitis (“sausage fingers”), “pencil-in-cup” deformity on x-ray?

Answer 33

Psoriatic arthritis

Question 34

ankylosis (stiff spine due to fusion of joints), uveitis, aortic regurgitation?

Answer 34

Ankylosing spondylitis

Question 35

Ankylosing spondylitis what kind of spine do you get?

Answer 35

Bamboo spine (vertebral fusion)

Question 36

Young male weeks after GI (YES Campy Salmon) or Chlymydia infection has?

Answer 36

Reactive arthritis (Reiter syndrome)

Question 37

Reactive arthritis (Reiter syndrome) has three syndromes?

Answer 37

Conjunctivitis and anterior uveitis, Urethritis, Arthritis

Question 38

A female with SLE has a vegetation what is this?

Answer 38

Libman-Sacks endocarditis—nonbacterial, wart- like vegetations on both sides of valve.

Question 39

A female with SLE has a glomerulonephritis? What are the two? Which one is worse?

Answer 39

Nephritic—diffuse proliferative glomerulonephritis (worse); ƒ Nephrotic—membranous glomerulonephritis

Question 40

SLE has what kind of rash?

Answer 40

Malar Rash upon sunlight

Question 41

SLE has a heme disorder, what is it?

Answer 41

Anemia, Thrombocytopenia or leukopenia=>Avascular necrosis

Question 42

Avascular Necrosis in SLE is what HSR?

Answer 42

Type 2 HSR

Question 43

What are specific antibodies for SLE?

Answer 43

Anti-dsDNA antibodies, Anti-Smith antibodies-

Question 44

if you have Anti-dsDNA antibodies, prognosis?

Answer 44

Poor

Question 45

Anti-Smith antibodies is a?

Answer 45

snRNP

Question 46

Antihistone antibodies is for?

Answer 46

SHIPP, Drug induced lupus

Question 47

What will be decreased in SLE?

Answer 47

Complement

Question 48

5 year survival for SLE?

Answer 48

>90%

Question 49

Hypercoagulable State+PTT=?

Answer 49

Antiphospholipid syndrome

Question 50

Antiphospholipid syndrome what is weird?

Answer 50

Increased PTT

Question 51

CXR in a sarcoid patient?

Answer 51

bilateral adenopathy and coarse reticular opacities

Question 52

Sarcoid you will see what kind of bodies?

Answer 52

asteroid bodies

Question 53

Sarcoid, the hypercalcemia is due to?

Answer 53

Increased 1α-hydroxylase–mediated vitamin D activation in macrophages

Question 54

Sjorgen vs Sarcoidosis?

Answer 54

Sarcoids have noncaseting granuloma

Question 55

Any disease with noncaseting granuloma=?

Answer 55

Hypercalcemia

Question 56

Anti-Jo-1 is associated with?

Answer 56

Polymyositis/dermatomyositis

Question 57

Dermato is closer to the skin so?

Answer 57

it affects the perimesum

Question 58

Malar rash similar to SLE and heliotropic rash (perioribtal) and Grotton's Lesions?

Answer 58

dermatomyositis

Question 59

Polymyositis affects Endomyseium therefore, it is asscoiated with?

Answer 59

CD EIGHT

Question 60

Bilateral proximal muscle weakness is associated with?

Answer 60

Dermatomyosities (getting up for the DOOR)

Question 61

With dermatomyositis, there is an increased risk of?

Answer 61

Occult malignancy like gastric cancer

Question 62

Mysoitis ossificans is a ________ of skeletal muscle into bone?

Answer 62

Metaplasia

Question 63

Mysoitis ossificans presents as a suscepicious __________ of known trauma?

Answer 63

Mass