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MSK > Dermatology > Flashcards

Dermatology Flashcards

1
Q

stem cell site?

A

Stratum Basale

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2
Q

desmosomes?

A

Stratum Spinosum

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3
Q

keratin?

A

Stratum Corneum

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4
Q

Freckle, labial macule are due to increased?

A

of melanosomes

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5
Q

Psoriasis is due to increased?

A

Hyperkeratosis and Parakeratosis

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6
Q

Hyperkeratosis?

A

Increased thickness of stratum corneum

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7
Q

Parakeratosis

A

Hyperkeratosis with retention of nuclei in

stratum corneum

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8
Q

Eczematous dermatitis that has skin erythema, vesicles and oozing over the upper eye lids?

A

Spongiosis

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9
Q

Spongiosis?

A

Epidermal accumulation of edematous fluid in intercellular spaces

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10
Q

Pemphigus vulgaris?

A

Acantholysis

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11
Q

Acantholysis?

A

Separation of epidermal cells

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12
Q

Acanthosis nigricans?

A

Epidermal Hyperplasia (increased spinosum)

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13
Q

Normal melanocyte number with decreased 􏰂melanin production?

A

Albinism

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14
Q

Albinism MOA?

A

defective tyrosine transport OR failure of neural crest cell migration

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15
Q

Albinism leads to increased risk of?

A

Skin Cancer

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16
Q

Hyperpigmentation associated with pregnancy ?

A

Melasma (chloasma)

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17
Q

Patchy areas of complete depigmentation?

A

Vitiligo

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18
Q

Vitiligo MOA?

A

Autoimmune destruction of melanocytes

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19
Q

P.Acnes MOA?

A

P. Acnes=>lipases=>inflammation

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20
Q

Allergic contact dermatitis HSR?

A

Type IV hypersensitivity reaction that follows exposure to allergen

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21
Q

Papules and plaques with silvery scaling H , especially on knees and elbows?

A

Psoriasis

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22
Q

pin point bleeding spots from exposure of dermalpapillae when scales are scraped off

A

Auspitz sign

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23
Q

nail pitting?

A

Psoriasis

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24
Q

Psoriasis with parakeratotic scaling is with?

A

Increased 􏰀stratum spinosum,􏰂 decreased stratum granulosum

25
Q

Epithelial proliferation with keratin-filled cysts that looks it can peeled off

A

Seborrheic keratosis

26
Q

Leser-Trélat sign?

A

sudden appearance of multiple seborrheic keratoses, indicating an underlying malignancy (e.g., GI, lymphoid).

27
Q

HPV. Soft, tan-colored, cauliflower-like papules ?

A

Verrucae

28
Q

Pruritic eruption, commonly on skin flexures like antecubital fossae; Commonly associated with eating certain foods

A

Atopic dermatitis (eczema)

29
Q

Atopic dermatitis (eczema) HSR?

A

Type 1 HSR

30
Q

Highly contagious. Honey- colored crusting? MC?

A

Impetigo; S. aureus.

31
Q

Acute, painful, spreading infection of deeper dermis and subcutaneous tissues? MC?

A

Cellulitis=>S. pyogenes or S. aureus

32
Q

Deeper tissue injury, usually from anaerobic bacteria?

A

Necrotizing fasciitis

33
Q

Staphylococcal scalded skin syndrome is due S. Aureus toxins?

A

Exfoliative toxin A and B

34
Q

Umbilicated papules caused by a poxvirus in children, it may be sexually transmitted in adults?

A

Molluscum contagiosum

35
Q

white, painless plaques on tongue that cannot be scraped off?

A

Hairy leukoplakia

36
Q

Hairy leukoplakia is due to?

A

EBV

37
Q

Hairy leukoplakia is usually on what side of the tongue?

A

Lateral

38
Q

IgG antibody against desmoglein (component of desmosomes) in Stratum spinosum?

A

Pemphigus vulgaris

39
Q

IF in Pemphigus Vulgaris?

A

antibodies around epidermal cells in a reticular (net-like) pattern

40
Q

Separation of epidermis upon manual stroking of skin is seen in?

A

Pemphigus vulgaris

Nikolsky sign ⊕

41
Q

IgG antibody against hemidesmosomes (epidermal basement membrane)?

A

Bullous pemphigoid

42
Q

In Bullous Pemphigoid, Tense blisters containing eosinophils affect skin but spare

A

oral mucosa

43
Q

IF in Bullous Pemphigoid?

A

linear pattern at epidermal-dermal junction

Negative Nikolsky sign

44
Q

Dermatitis herpetiformis?

A

Associated with celiac disease.

45
Q

Erythema multiforme MC seen in?

A

HSV

46
Q

Epidermal hyperplasia causing symmetric, hyperpigmented thickening of skin

A

Acanthosis nigricans

47
Q

Acanthosis nigricans is associated with?

A

hyperinsulinemia (e.g., diabetes, obesity, Cushing syndrome), visceral malignancy (e.g., gastric adenocarcinoma)

48
Q

Premalignant lesions caused by sun exposure?

A

Actinic keratosis

49
Q

Actinic keratosis increases risk for?

A

squamous cell carcinoma

50
Q

Lichen Planus 6 P’S

A

Pruritic, Purple, Polygonal Planar Papules and Plaques are the 6 P’s of lichen Planus

51
Q

Lichen planus manifests as?

A

Mucosal involvement manifests as Wickham striae (reticular white lines)

52
Q

Lichen planus has what kind of appearance?

A

Sawtooth

53
Q

Lichen planus is associated with?

A

HCV

54
Q

atypical kertinocytes with hyperkeratosis and parakeratosis?

A

Actinic Keratosis

55
Q

HLA-C is seen in?

A

Psoriasis

56
Q

Psoriasis treatment?

A

UVA

57
Q

Why is vit. A a good treatment in Acne?

A

Decreases keratin products

58
Q

In Hives, you will see increased?

A

Dermal edema

MSK (13 decks)

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