MSK Pharm Flashcards
Reversibly inhibits cyclooxygenase, mostly in CNS. Inactivated peripherally?
Acetaminophen
Acetaminophen toxicity?
metabolite (N-acetyl-p-benzoquinone imine) depletes glutathione and forms toxic tissue byproducts in liver
Antidote?
NAC
Acetaminophen causes damage to which zone?
Zone 3 Centrilobular
Celecoxib Use? AE?
Use: Spare Gastric Mucosa
AE: Increased risk of thrombosis
Bisphosphonate MOA?
MOA: bind hydroxyapatite in bone, inhibiting osteoclast activity
Bisphosphonate AE?
AE: Corrosive esophagitis (patients are advised to take with water and remain upright for 30 minutes)
Teriparatide MOA?
MOA: Recombinant PTH analog given subcutaneously daily. Increases osteoblastic activity.
Teriparatide AE?
AE: risk of osteosarcoma (seen in rodent studies).
Allopurinol MOA?
MOA: Inhibits xanthine oxidase after being converted to alloxanthine
Allopurinol AE?
AE: Increased concentrations of azathioprine and 6-MP
Febuxostat MOA?
MOA: Inhibits xanthine oxidase.
Pegloticase
MOA: Recombinant uricase that catalyze metabolism of uric acid to allantoin
Probenecid MOA?
MOA: Inhibits reabsorption of uric acid in proximal convoluted tubule
Probenecid AE?
Increases pencillin levels
Strongest NSAID?
indomethacin
Colchicine MOA?
MOA: Binds and stabilizes tubulin to inhibit microtubule polymerization, impairing neutrophil chemotaxis and degranulation.
Colchicine AE?
Diarrhea, vomiting and nausea
Etanercept MOA?
MOA: “InterCEPTS”; Fusion protein (receptor for TNF-α + IgG1 Fc),
Infliximab, adalimumab MOA?
MOA: Anti-TNF-α monoclonal antibody.
1st and 2nd line for acute gout?
1st=>COX inhibitors
2nd=>colchicine
