Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

MSK > MSK Pharm > Flashcards

MSK Pharm Flashcards

1
Q

Reversibly inhibits cyclooxygenase, mostly in CNS. Inactivated peripherally?

A

Acetaminophen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Acetaminophen toxicity?

A

metabolite (N-acetyl-p-benzoquinone imine) depletes glutathione and forms toxic tissue byproducts in liver

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Antidote?

A

NAC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Acetaminophen causes damage to which zone?

A

Zone 3 Centrilobular

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Celecoxib Use? AE?

A

Use: Spare Gastric Mucosa
AE: Increased risk of thrombosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Bisphosphonate MOA?

A

MOA: bind hydroxyapatite in bone, inhibiting osteoclast activity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Bisphosphonate AE?

A

AE: Corrosive esophagitis (patients are advised to take with water and remain upright for 30 minutes)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Teriparatide MOA?

A

MOA: Recombinant PTH analog given subcutaneously daily. Increases 􏰀osteoblastic activity.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Teriparatide AE?

A

AE: risk of osteosarcoma (seen in rodent studies).

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Allopurinol MOA?

A

MOA: Inhibits xanthine oxidase after being converted to alloxanthine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Allopurinol AE?

A

AE: Increased concentrations of azathioprine and 6-MP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Febuxostat MOA?

A

MOA: Inhibits xanthine oxidase.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Pegloticase

A

MOA: Recombinant uricase that catalyze metabolism of uric acid to allantoin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Probenecid MOA?

A

MOA: Inhibits reabsorption of uric acid in proximal convoluted tubule

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Probenecid AE?

A

Increases pencillin levels

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Strongest NSAID?

A

indomethacin

17
Q

Colchicine MOA?

A

MOA: Binds and stabilizes tubulin to inhibit microtubule polymerization, impairing neutrophil chemotaxis and degranulation.

18
Q

Colchicine AE?

A

Diarrhea, vomiting and nausea

19
Q

Etanercept MOA?

A

MOA: “InterCEPTS”; Fusion protein (receptor for TNF-α + IgG1 Fc),

20
Q

Infliximab, adalimumab MOA?

A

MOA: Anti-TNF-α monoclonal antibody.

21
Q

1st and 2nd line for acute gout?

A

1st=>COX inhibitors

2nd=>colchicine

MSK (13 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions