Skin Cancer

Question 1

Sunburn causes? and it is done by?

Answer 1

DNA mutations, inducing apoptosis of keratinocytes

UVB

Question 2

UVB can lead to?

Answer 2

Basal cell carcinoma

Question 3

Basal cell carcinoma is most commonly found in?

Answer 3

Upper Lip

Question 4

Basal cell carcinoma presents as

Answer 4

Pink, pearly nodules, commonly with telangiectasias

Question 5

Basal cell carcinoma has what kind of nuclei?

Answer 5

Palisading nuclei

Question 6

Risk factors of BCC?

Answer 6

Xeroderma pigmentosum

Question 7

Xeroderma pigmentosum is due to?

Answer 7

Nucleotide excision repair

Question 8

Skin Cancer is a bunch of B/S?

Answer 8

BCC=> Upper Lips

SCC=> Lower Lips

Question 9

SCC is associated with two things?

Answer 9

1. Immunosuppression

2. Arsenic Exposure

Question 10

SCC has two other risk factors?

Answer 10

3rd degree burns and draining sinus tract

Question 11

Keratoacanthoma does it grow rapidly? regress?

Answer 11

Yes, Yes!

Question 12

ABCDEs?

Answer 12

Asymmetry, Border irregularity, Color variation, Diameter > 6 mm, and Evolution over time.

Question 13

Worst of the melanoma?

Answer 13

Nodular

Question 14

MC of melanoma?

Answer 14

superficial spreading

Question 15

Melanoma is associated with what mutation?

Answer 15

BRAF kinase.

Question 16

What is a BRAF kinase inhibitor?

Answer 16

Vemurafenib=>BRAF kinase inhibitor

Question 17

Melanin is made in?

Answer 17

Melanosomes

Question 18

Melanin origin?

Answer 18

Neural Crest

Question 19

With melanin what increases risk of metathesis?

Answer 19

Depth of Invasion

Question 20

Skin becomes scaling with only minimal exposure?

Answer 20

Xeroderma Pigmentosum

Question 21

Melanoma loves to go to the?

Answer 21

Brain

Question 22

Mutated BRAF will knock out?

Answer 22

NRAS