Systemic antimicrobials In periodontal therapy- part 1 Flashcards
Name and describe the different stages of periodontitis
Stage I: Initial periodontitis
Stage II: Moderate periodontitis
Stage III: Severe periodontitis with potential for additional tooth loss
Stage IV: Severe periodontitis with potential for loss of the dentition
What is the extent and distribution of periodontitis?
Localised, generalised, Molar- Incisor distribution
What are the grades of periodontitis
A ; Slow rate of progression
B: Moderate rate
C: Rapid rate of progression
what are antibtiotics?
Drugs that kill or halt the multiplication of bacterial cells at concentrations that are relatively harmless to host tissues and therefore can be used to treat infections by bacteria
Name and describer how antibiotics are classified
Beta- lactase e.g. penicillins (Beta lactase inhibitors- co amoxiclav
Aminoglycosides e.g Gentamicin
Sulphonamides e.g Sulfa/ sulpha group
Tettracyclines e.g doxy, mino
Azoles - e.g metronidazole
Quinolones - e.g Ciporfloxacin
Macrolides - E.g Erthyomycin, Azithormycin
Others - e.g clindamycin
what do tetracyclines and macroldies do
inhibit protein synthesis
what is the mode of action of systemic antibiotics
- Inhibition of cell wall synthesis
- Inhibition of cytoplasmic membrane function
- Inhibition of nucleic acid synthesis
- Inhibition of ribosomal function and hence protein synthesis
- Inhibition of folate metabolism
what do amoxycillin do
inhibit cell wall synthesis
What do metronidazole do
Inhibit nucleic acid synthesis by breaking down strands of DNA
What re the disadvantages of the use of antibiotics
- possible adverse effects
- hypersensitivtiy
- gastrointestinal disturbances
-Alterations in commensal flora e.g Oral candidiasis , pseudomembranous colitis - Drug interactions - alcohol - Disufiram/ potential of anitcoagulanat effect/ avoid during pregnancy
- Bacterial resistance
How many deaths were estimated in the 2009 European centre for disease prevention with AMR (Antimibrial resistance)
25,000
cost 1.5 billion in extra healthcare
what is the antimicrobial stewardship programme- NICE
An organisational or healthcare system wide approach to promote monitoring of judicious use of anti microbials to preserve their future effectiveness
Describe anitmicrobila stewardship
Primary care prescribing alters risk of anitbitoic resistance in an individual
- Evidence based optimal standards for routine antimicrobial prescribing
Ensuring competency and education for prescribers
- Communication of issue to all stake holders
-Auditing the impact and uptake of processes above
- Optimizing outcome for patients presided anitmicorbials
what does the anitbitoic guardian support
The UK antimicrobials resistance strategy
- Don’t demand antibiotics
- Take antibiotics as they are prescribed to use
-Spread the work among friends and relatives
What are factors affecting AMR efficacy
- Binding of drug to tissue
- protection of key organisms by non target organisms binding or consuming drug
-Bacterial tissue invasion
-Total bacterial load - Previous drug therapy
- Non pocket infected sites
– Choice of bactericidal drug vs bacteriostatic drug (prevent growth of bacteria ) - Presence of biofilms - must disrupt
Beta - lactase production
some bacteria produce beta-lactaamase ( there are > 100 different types known)
which can inactivate beta- act drugs eg. pencillin
Clavulanic acid - beta lactamase inhibitor sometimes used in combination with amoxicillin to prevent this