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Periodontics II > Systemic Antibiotics > Flashcards

Systemic Antibiotics Flashcards

1
Q

Need info from slide

A

1-25

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2
Q

Metronidazole is

A

bacteriocidal aganst anaerobic bacteria

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3
Q

Metronidazole inhibits

A

DNA synthesis

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4
Q

Metronidazole in DNA replication does

A

inserts itself in the double strand

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5
Q

Metronidazole is used alone or with other ant.?

A

can be used alone but most of the time with other ant.

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6
Q

Metronidazole used with

A

PCN

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7
Q

Metronidazole is ineffective alone against

A

A.A.

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8
Q

side effects of Metronidazole

A 
antabuse type reaction
metallic taste
orange urine
Nausea and vomiting
peripheral neuropathy (infrequent)
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9
Q

Clindamycin is used when

A

PCN doesnt work/allergices

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10
Q

Clindamycin is good

A

anaerobic coverage
inhibits protein systhesis
bacteriostatic

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11
Q

Clindamycin side effects

A

risk of pseudomembranous colitis due to growth of clostridium difficile, skin rash

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12
Q

Azithromycin is

A
  • effective against anaerobes and gram neg bacilli
  • penetrates fibroblastsand phagocytes
  • concentration are sig higher in periodontallesions compared to normal gingiva
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13
Q

if systemic antimicrobials are indicated as part of periodontal therapy, they should be_____ to mechanical debridement.

A

adjunctive

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14
Q

there is____ to recommend a specific protocol for the use of adj. systemic antimicrobial with nonsurgival mech debridement

A

no direct evidence

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15
Q

there is ____ that antibiotitcs in take should start on the day the debriment completion, debridement should be completed within a ___

A

indirect evidence, short time (

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16
Q

drugs that modulate host respnse

A
  • non steroidal anti inflammatory drugs (NSAIDS)

- subantimicrobial dose of doxyclyclinse (Periostat)

17
Q

periostate significance

A
  • way below dose used for infectinos
  • the mech is for anticollagenase activity alone, inhibiting protein synthesis in bacteria cells
  • min risk of bacterial resistance to tetracyclines
18
Q

chemotherapeutic agents is a term

A

for a chemical substance that provides clinical therapeutic benifits

19
Q

clinical benifits of chemotherapeutic agents

A
  • antimicrobial actions

- ability to increase the host’s resistance.

20
Q

in systemic antibiotics, there is

A

No evidence that antibiotics alone can arrest

periodontal disease.

21
Q

in systemic antibiotics, the Greatest benefit in :

A
  • the presence of systemic disease
  • immunocompromised patients
  • aggressive forms of periodontal disease
  • patients who are not good candidates for more complex and invasive treatment
22
Q

Chronic periodontitis can and should be treated initially ______ systemic antibiotics.

A

without

23
Q

The clinical diagnosis and situation dictate theneed for possible antibiotic therapy as an adjunct in controlling __________.

A

active periodontal disease.

24
Q

Periodontal disease is predominately a gram _____ anaerobic infection

A

negative

25
Q

When should you consider the use of systemic antibiotics during periodontal therapy?

A
  • Aggressive periodontitis
  • Necrotizing ulcerative periodontal disease
  • “Refractory Periodontitis” or patients who are considered to be high risk
  • Generalized severe chronic periodontitis
  • Periodontal patients who are immunocompromised
  • Heavy smokers
  • In conjunction with certain surgical procedures (implants, bone grafting, sinus lifts, Guided tissue regeneration)
26
Q

Penicillians MOA, spectrum, effect

A

Inhibits cell wall syn, narrow, bacteriocidal

27
Q

Frequently used penicillins (PCNs) in periodontal therapy include

A
  • Amoxicillin
  • Pen VK
  • Amoxicillin with clavulanic acid Augmentin)
28
Q

Tetrcyclines moa, spectrum and effect

A

inhibits protein synthesis, broad, bacteriostatic

29
Q

Tetrcyclines indications

A
  • “Refractory” Periodontitis

- Aggressive Periodontitis (EOP)

30
Q

Tetrcyclines advantages

A

-Ability to concentrate in the tissues and
destroy A.a.
-Anticollagenase activity

31
Q

tetrcyclines contraindications

A
  • dont give with milk/dairy, Fe containing vitamins and minerals orantacids
  • photosensitivity
  • avoid use in children, preg/nurs (may cause discoloration of teeth)
32
Q

forms of tetracyclines used in perio

A

doxycyline

minocycline

33
Q

doxycyline is _____ on the stomach than mino. and tetr.

A

eaiser

34
Q

can you take dairy with doxycyline

A

yes

Periodontics II (10 decks)

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