Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Bacteriology > Syphilis and Lyme Disease > Flashcards

Syphilis and Lyme Disease Flashcards

1
Q

What are the 3 medically important spirochetes?

A

Treponema pallidum - Syphilis
Borrelia burgdorferi - Lyme disease
Leptospira species - Leptospirosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Which spirochete is a strict human pathogen?

A

Treponema pallidum

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What presentation is associated with primary syphilis?

A

Painless ulcer (chancre)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What presentation is associated with secondary syphilis?

A 
"Flu like" illness with lymphadenopathy
Disseminated rash (including palms and soles)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What presentation is associated with tertiary or late syphilis?

A

Chronic inflammation with granulomatous lesions in CNS (neurosyphilis) and blood vessels (cardiovascular syphilis)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What presentation is associated with congenital syphilis?

A

Fetal disease with latent manifestations or multiorgan malformations

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What is diagnostic test of choice for Treponema pallidum (syphilis)?

A

Serology

  • Non treponemal tests (VDRL, RPR): not diagnostic of syphilis but points in that direction
  • Treponemal test: done second, more specific antibody for syphilis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is treatment of choice for Treponema pallidum?

A

Penicillin (not a lot of resistance in syphilis) or doxycycline
For neurosyphilis, give ceftriaxone (better CSF penetration)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What animals are common reservoirs for Borrelia (lyme disease)?

A

White footed mouse, white tailed deer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What presentation is associated with early localized lyme disease?

A

Erythema migrans (bullseye looking rash)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What presentation is associated with early disseminated lyme disease?

A 
Multiple erythematous lesions
Myalgias, arthralgia, headache, fatigue
Cranial nerve palseies (CNVII) - pretty much Bell's palsy
Meningitis
Cardiac dysfunction
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What presentation is associated with late disseminated disease?

A

Mostly arthritis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What is diagnostic test of choice for lyme disease?

A

Serology

- Must confirm with western blot!!

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is treatment for lyme disease (Borrelia)?

A

Doxycycline

Ceftriaxone for severe disease (i.e. with meningitis)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

How is Leptospira transferred?

A

Carrier animals excrete urine into environment, humans contract through direct contact or cuts in skin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What presentation is associated with Leptospira?

A

Usually asymptomatic or only fever

Can cause biphasic (septicemic and immunologic) severe leptospirosis disease

17
Q

What is diagnostic test of choice for leptospirosis?

A

Microscopic agglutination test (MAT)

18
Q

What is treatment for leptospirosis?

A

Supportive management essential

Penicillin, doxycycline, ceftriaxone

Bacteriology (19 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions