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Bacteriology > Rickettsia > Flashcards

Rickettsia Flashcards

1
Q

What organism causes Rocky Mountain Spotted Fever?

A

Rickettsia rickettsii

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2
Q

How is Rickettsia rickettsii transmitted?

A

Tick bite

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3
Q

What is clinical presentation of Rocky Mountain Spotted fever?

A

Fever, headache, myalgia, maculopapular-petechial rash

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4
Q

What organism causes Murine typhus?

A

Rickettsia typhi

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5
Q

How is Rickettsia typhi transmitted?

A

Fleas, associated with rat infestation

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6
Q

What is clinical presentation of Murine typhus?

A

Fever, headache, myalgia, maculopapular rash on trunk

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7
Q

What is underlying pathology of Rocky Mountain Spotted fever and Murine typhus?

A

Infection of endothelial cells

Causes lymphohistiocytic vasculitis (blood vessel inflammation and damage) resulting in loss of intravascular fluid

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8
Q

What are complications of Rocky Mountain Spotted fever and Murine typhus?

A

Hypotension (Both)
End-organ ischemic injury (Both)
Cerebral edema (RM Spotted fever)
Pulmonary edema (RM Spotted fever)

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9
Q

What diagnostic techniques are used to make the diagnosis of Rocky Mountain Spotted fever and Murine typhus?

A 
SEROLOGY
And clinical (hx of exposure to tick or flea, fever, headache)
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10
Q

What organism causes human Monocytic ehrlichiosis (HME)?

A

Ehrlichia chaffeensis

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11
Q

What organism causes human granulocytic anaplasmosis (HGA)?

A

Anaplasm phagocytophilum

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12
Q

What is the clinical presentation of HME and HGA?

A

Fever, headache, myalgia (no rash)

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13
Q

In what locations is HME usually found vs. HGA?

A

HME - southeast and southcentral US

HGA - northeast and upper midwest US, Europe, East Asia

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14
Q

How can Rocky Mountain spotted fever and Murine typhus be differentiated from HME and HGA using complete blood count (CBC) results?

A

Rocky Mountain spotted fever and Murine typhus - NORMAL white blood cell count with left shift

HME and HGA - LOW white blood cell count with left shift

All exhibit thrombocytopenia

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15
Q

What is the underlying pathology of HME and HGA?

A

Infection of leukocytes; no vasculitis

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16
Q

What are complications of HME and HGA?

A

Hypotension

Mild hepatitis

17
Q

What diagnostic techniques are used to make the diagnosis of HME and HGA?

A 
SEROLOGY
And clinicopathology (tick bite, fever, leukopenia)
18
Q

What is the treatment for all Rickettsial disorders?

A

Doxycycline

Bacteriology (19 decks)

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