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Block 3 Up To Quiz 1 > Synaptic Transmission > Flashcards

Synaptic Transmission Flashcards

1
Q

synaptic transmission

A

electrical and chemical means that neuron use to signal between cells

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2
Q

neuron strcuture

A

4 regions: cell body, dendrites, axon, presynaptic termini (some have no dendrites others no axon most have all 4 though)

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3
Q

synapse

A

site of interaction between neurons in nervous system and target cells (transmits information from one neuron to next)

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4
Q

types synaptic contact that can occur

A

axosomatic, axodendritic, axoaxonic

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5
Q

axosomatic

A

axon terminating on cell soma of another neuron

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6
Q

axodenderitic

A

axon terminating on dendrite of another neuron

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7
Q

axoaxonic

A

axon terminates on another axon

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8
Q

presynaptic terminal

A

where upstream axon talks to downstream axon

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9
Q

types of synaptic transmission

A

electrical or chemical

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10
Q

synaptic structure

A

synapse involves apposition of presynaptic neuron and postsynaptic cell
- compartments of synapse: presynaptic terminal and postsynaptic site, synaptic cleft (chemical synapses only)

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11
Q

presynaptic termmial

A

where axondendritic synapses would be at end of axon

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12
Q

postsynaptic site

A

on dendrite opposite presynaptic terminal on receiving neuron

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13
Q

synaptic cleft

A

chemical synapses which separate presynaptic terminal and postsynaptic site

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14
Q

electrical synapses

A
  • gap junctions

- present in heart and NS but mostly in heart most NS synapses are chemical

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15
Q

gap junction structure

A

multipliers of connexin protein which will form pore connecting cells -
- facilitate v fast transmission from one cell to next

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16
Q

what can be transmitted across gap junction

A
  • action potential passively transmitted as current
  • small molecules like cAMP and some neurotransmitters can also be passed from one cell to next
  • gap jnxs can coordinate actions of number cells by electrically connecting them
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17
Q

chemical vs electrical synapses

A

electrical are faster but chemicals are more flexible

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18
Q

chemical synapse

A

gap between neuron bridged by release of chemical signal called neurotransmitter from presynaptic ternimal

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19
Q

neurotransmitter classical criteria

A
  1. classical neurotransmitters produced and stored (and therefore, can be localized) within a neuron
  2. When a neuron is stimulated (depolarized) a neurotransmitter is released by neuron. Release is dependent upon calcium
  3. Neurotransmitters must be inactivated
  4. When neurotransmitter released it acts upon post-synaptic receptor to cause biological effect
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20
Q

general categories neurotransmitters

A

small molecules (includes small molecules, monoamines, animo acids, catecholamines) and neuropeptides

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21
Q

small molecules

A

acetylcholine

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22
Q

animo acids

A

glutamate, GABA, Glycine

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23
Q

monoamines

A

serotonin, histamine

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24
Q

catecholamines

A

dopamine, norepinephrine, epinephrine

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25
Q

small molecules synthesized where transported how

A

enzymes that make them made in cell body then enzymes transported via slow axonal transport from cell body to presynaptic terminal; small molecule neurotransmitters synthesized from component parts at presynaptic terminal vesicles loaded at synaptic terminal where small molecules are made

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26
Q

what enzyme is made to use acetylcholine

A

choline acetyl transferase

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27
Q

neuropeptide synthesized wehre transported how

A

synthesized in cell body and packaged into vesicles here then transported by fast axonal transport

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28
Q

acetylcholine synthesized from

A

Acetyl-coA and choline by choline acetyltransferase in presynaptic terminal (these component parts aren’t sitting around presynaptic terminal they are sitting in vesicles docked at cleft waiting for release)

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29
Q

small molecule vs neuropeptide synthesis location

A

small molecules synthesized in presynatic terminal neuropeptide synthesis occurs in cell body

30
Q

vesicles small molecules vs vesicles neuropeptides

A

vesicles containing small molecules can be docked at presynaptic terminal membrane and primed for release; vesicles containing neuropeptides are not docked

31
Q

what is being moved in fast vs slow axonal transport

A

enzymes that make small molecules transported in slow axonal transport while neuropeptides are transported by fast axonal transport (neuropeptides are in vesicles when they’re being transported by fast axonal transport)

32
Q

how is neurotransmitter released

A

Chemical synapses defined by presence of synaptic vesicles which are filled with neurotransmitter which gets released when vesicle fuses with terminal membrane
- action potential travels down axon and enters presynaptic terminal, voltage-gated calcium channels ion terminal open -> calcium flows into terminal -> calcium triggers fusion vesicle with membrane -> release neurotransmitter into cleft

33
Q

vesicle fusion

A

dependent upon SNARE proteins and calcium

34
Q

major v snares

A

synaptobrevin and synaptotagmin

35
Q

major t snares

A

syntaxin and SNAP-25

36
Q

what leads to fusion

A

interaction synaptobrevin with vesicle and syntaxin and SNAP-25 on terminal membrane brings each vesicle loaded with neurotransmitter in contact with release site, fusion and release occur if synaptotagmin binds calcium which requires voltage gated calcium channels open in terminal bc action potential

37
Q

after neurotransmitter release

A

vesicles recycled using other proteins and refilled

38
Q

toxins and vesicular fussion

A

natural toxins can:
prevent fusion of vesicles:
including tetanus toxin and botulinum toxins B, D, F G (cleave synaptobrevin) Botulinum toxins C1 and A/E (cleave syntaxin and SNAP-25), Conotoxins (block calcium channels necisary for vesicular release)
Medite fusion and release of vesicles even in absence of calcium
= Latrotoxin (black widow spider)

39
Q

Cotransmitters

A

most neurons secrete more than one neurotransmitter providing additional flexibility and modulation of signal

  • single actin potential produces transient rise in Ca2+ -> immediate release docked small molecule vesicles into cleft
  • series action potentials in close temporal order -> prolonged elevated level calcium -> release vesicles containing neuropeptides (this allows strength of signal to be passed on to next neuron via use multiple transmitters)
40
Q

neurotransmitter inactivation

A
  • necessary because once signal passed onto post-synaptic cell must be turned off so cycle can begin again
  • usually involves one or more of:
    1. Removal by specific transport proteins
    2. Diffusion
    3. Degredation by transmitter-specific enzymes
41
Q

acetylcholine inactivation

A

removal of acetylcholine in cleft mediated by acetylcholinesterase (enzyme) which produces acetate and choline
- choline diffusies away from cleft and recycled into presynaptic terminal by high-affinity choline transporters; this lets cell inactivate neurotransmitter and avoid having to synthesize new one

42
Q

what happens once choline in terminal

A

choline acetyl transferase adds acetyl group to choline to regenerate acetylcholine which is imported into vesicles so cycle can repeat

43
Q

glutamate inactivation

A
  • no enzymes specifically for degradation glutamate in synaptic cleft
  • diffusion and uptake via glutamate transporters remove glutamate and recycle it into presynaptic terminal
  • glutamate can also be removed by glutamate transporters on glia surrounding synapse w/in glial cell glutamate converted -> glutamine -> released -> glutamine taken up into presynaptic terminal via transporters -> glutamine converted -> glutamate -> vesicles refilled with glutamate
44
Q

agents affecting neurotransmitter inhibition

A
  • acetylcholinesterase inhibitors (acetylcholinesterase mediates removal acetylcholinesterase in cleft)
  • Ache inhibitors (nerve agents Sarin and VX1), Malathione
  • Anti-Depressants affect neurotransmitter transporers
45
Q

neurotransmitter receptor diversity

A

more varieties receptors than specific neurotransmitters; this variety provides additional ways of regulating information flow

46
Q

2 general classes neurotransmitter receptors

A
  • ionotropic

- metabotropic

47
Q

inotropic receptors

A
  • ligand gated ion channels
  • direct effect
  • binding of neurotransmitter -> opening channel -> ions flowing in or out of cell
48
Q

Major neurotransmitter of neuromuscular junction

A

Ach

49
Q

Ach

A

mediates fnx at neuromuscular junction via inotropic receptor (aka nicotinic Ach receptor)

50
Q

What happens when Ach released by presynaptic motoneuron onto muscle fiber

A

Ach diffuses across cleft -> binds to inotropic Ach receptor -> opening channel -> depolarization (excitatory response) -> muscle fiber contraction

51
Q

ligand gated channel Ach

A

Ligand gated channel opens when Ach binds this is non-selective cat ionic channel so when it opens cations like Na+ and K+ can flow through so Na+ influxes K+ effluxes -> cell depolarizing

** these channels are not activated by depolarization they are activated by binding of ligand**

52
Q

GABA effect on target neurons ionotropic receptor

A

usually mediates inhibitory (hyperpolarization) effect on target neurons

53
Q

How does GABA -> inhibition with ionotropic recceptor

A

GABA released by presynaptic neuron onto post synaptic neuron -> binds GABA specific ionotropic receptor ->channels open allowing chloride to enter cell -> inhibition

54
Q

Metabotropic receptors

A
  • G protein coupled receptors
  • indirect effect
  • neurotransmitter binds -> activation effector protein class (G proteins) -> activate variety other intracellular effects
  • post synaptic effects can take longer than inotropic receptors but changes an last longer and this process can amplify signal
55
Q

Ach effect on heart

A
  • due to metabotropic acetylcholine receptor (Ach receptor)

- slows down heart rate

56
Q

metabotropic acetylcholine receptor in heart aka

A

muscarinic Ach receptors

57
Q

ionophore acetylcholine receptor smooth muscle aka

A

nicotinic Ach receptor

58
Q

how does Ach effect heart steps

A
  1. Bind Ach to metallic receptor -> activation G protein complex
  2. beta-gamma subunit Gprotein activates G-protein inward rectifying potassium channel (GIRK) (specfilzied form of K+ channel)
  3. openning channel -> efflux K+ -> inhibitory post-synaptic potential

ALSO
- binding Ach to muscarinic receptor -> affect L-type Ca2+ channels through alpha (Gi) subunit which has additional inhibitory effect

59
Q

Other metabotropic Ach receptors

A
  • couple to different G-protein (Gq)
  • ex. smooth muscle: release Ach by parasympathetic neurons -> Ach binds receptor -> activation phospholipase C -> release Ca2+ -> muscle contraction
60
Q

Synapses/ neuron

A

individual neuron can have MANY synapses (in brain can have 1000s -> 100,000s)

  • synapses are from neighboring neurons
  • can be inhibitory, excitatory, modulatory
  • neurons have to integrate varied synaptic inputs and in turn produce action potential that influences other neurons
61
Q

dxs affecting synaptic transmission

A
  • myasthenia gravis
  • storage dx
  • LEMs
  • Epilepsy
  • ALS
62
Q

drugs affecting synaptic transmission

A
  • anti-psycotics
  • anti-depressants
  • barbiturates
  • all affect receptors/ enzymes/ transporters involved in transmission; many drugs bing GABA receptor
63
Q

epilepsy

A

loss inhibitory control in brain -> inappropriate excitation by gluatmate

64
Q

equinte motoneuron dx

A

vet equivalent ALS; influenced by distribution glutamate transporters in glial cells, affects slow axonal transport

65
Q

Myastenia Gravis

A

body attacks nicotinic Ach receptors; vet med correlate paraneoplatsic syndrome (thymoma -> autoimmune response)

66
Q

storage dx

A

affects neotramistter synthesis and release

67
Q

LEMs

A

produces autoimmune response against voltage-sensitive Ca2+ channels needed for vesicle fusion

68
Q

propagation of information in NS one way or two ways

A

it is two ways there is feedback

69
Q

autoreceptors

A
  • autoreceptors for released neurotransmitters often on presynaptic terminal as well as postsynaptic cells
  • these provide feedback to regulate amount of secreted enurotransmitter
70
Q

metabotropic glutamte receptors expressed on

A

presynaptic terminals and postsynaptic cells

71
Q

effect metabotropic glutamate receptors on presynaptic terminals

A
  • sense secreted amounts glutamate present in cleft
  • if levels too high activate autorceptors -> produce second messengers -> affect Ca2+ channels (reduce calcium input into terminal) or K+ channels (increasing repolarization following an action potential) via phosphorylation (both of these actions -> reduced amount secreted glutamate)
  • mGLuR’s also expressed on postsynaptic cells

Block 3 Up To Quiz 1 (24 decks)

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