Synaptic Transmission Flashcards
Metyrosine
Indication - Hypertension
Mechanism of action - Competitive inhibition of tyrosine hydroxylase
Reserpine
Indication - Hypertension
Mechanism of action - Inhibits VMAT uptake of monoamines
Bretylium
Indication - Ventricular arrhythmia
Mechanism of action - Inhibit action potential generation and calcium dependent synaptic vesicle fusion
Cocaine
Indication - Analgesia in surgery
Mechanism of action - Blocks monoamine reuptake
Amphetamine/Ephedrine
Indication - Narcolepsy, ADHD
Mechanism of action - Reverse monoamine reuptake transporters
Naloxone, Naltrexone
Indication - Opioid overdose or dependence
Mechanism of action - Non-peptide blockers of opioid receptors in CNS
SSRIs
Indication - Depression/anxiety
Mechanism of action - Selective inhibition of serotonin reuptake transporter
ACE inhibitors (e.g. lisinopril)
Indication - Hypertension
Mechanism of action - Inhibits peptide cleavage of Angiotensin I to Angiotensin II
Phenylephrine
Indication - Hypotension during surgery
Mechanism of action - Direct agonist of adrenergic receptor
MAO inhibitors
Indication - Depression
Mechanism of action - Blockade of cytoplasmic metabolism of monoamines
L-DOPA
Indication - Parkinson’s Disease
Mechanism of action - Precursor of dopamine, stimulates dopamine production
Side effects - Arrhythmia, dyskinesia
Carbidopa
Indication - Parkinson’s Disease
Mechanism - Blocks L-DOPA conversion to dopamine (aromatic acid decarboxylase inhibitor), does not cross BBB so protects peripheral adrenergic neurons from producing too much dopamine and NE
Side effects - Arrhythmia, dyskinesia
Tyramine
Indication - Ingested in diet, not therapeutic
Mechanism of action - Competes with NE for transport into synaptic vesicle
