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Pharm > Cholinergic Agonists & Antagonists > Flashcards

Cholinergic Agonists & Antagonists Flashcards

1
Q

Nicotine

A

Indication - Withdrawal symptoms of smoking cessation

Mechanism of action - Activation of neuronal nicotinic receptors

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2
Q

Succinylcholine

A

Indication - Neuromuscular block for electroconvulsive shock therapy or emergency intubation
Mechanism of action - Depolarizing block of muscle nicotinic receptors
Elimination - Plasma cholinesterase

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3
Q

Acetylcholine

A

Indication - No therapeutic use

Mechanism of action - Nicotinic and muscarinic agonist

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4
Q

Methacholine

A

Indication - Diagnosis of subclinical asthma, test for severity of asthma
Mechanism of action - Muscarinic agonist

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5
Q

Carbachol

A

Indication - Miotic agent in ocular surgery, to reduce pressure following ocular surgery
Mechanism of action - Muscarinic and nicotinic receptor agonist

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6
Q

Bethanechol

A

Indication - Urinary retention, bladder atony

Mechanism of action - Muscarinic agonist

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7
Q

Pilocarpine

A

Indication - Dry mouth from head and neck radiation or Sjogren’s syndrome, narrow angle glaucoma
Mechanism of action - Muscarinic agonist

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8
Q

Neostigmine

A

Indication - Myasthenia gravis, reverse neuromuscular block

Mechanism of action - Reversible AchE inhibitor

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9
Q

Edrophonium

A

Indication - Diagnosis of myasthenia gravis, reversal of neuromuscular block
Mechanism of action - Reversible AchE inhibitor

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10
Q

Physostigmine

A

Indication - Delirium from anticholinergic drugs (ie atropine poisoning), glaucoma
Mechanism of action - Reversible AchE inhibitor

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11
Q

Donepezil

A

Indication - Alzheimer’s disease

Mechanism of action - Reversible AchE inhibitor

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12
Q

Pralidoxime

A

Indication - Respiratory muscle weakness in organophosphate poisoning
Mechanism of action - Peripheral AchE reactivator

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13
Q

Echothiophate

A

Indication - Open angle glaucoma

Mechanism of action - Irreversible AchE inhibitor

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14
Q

Atropine

A

Indication - Excess secretions during surgery, the increased frequency and urgency associated with cystitis and hypertonic gut, organophosphate poisoning, bradycardia
Mechanism of action - Muscarinic antagonist

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15
Q

Scopolamine

A

Indication - Motion sickness, anti-salilagogue in surgery

Mechanism of action - Muscarinic antagonist

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16
Q

Glycopyrrolate

A

Indication - Protects against excessive muscarinic activation during reversal of neuromuscular blockade, anti-salilagogue
Mechanism of action - Muscarinic receptor antagonist

Pharm (8 decks)

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