Synapses 1 Flashcards
synaptic transmission
the process of information transfer at a synapse
electrical synapses
synaptic transmission that’s an electrical current flowing from one neuron to the next
common in mammal brain
chemical synapses
the idea that chemical neurotransmitters transfer information from one neuron to another at the synapse
CNS
majority of synapses in brain = chemical
presynaptic v postsynaptic
first neuron is pre, target cell is post
gap junction
specialized sites where electrical synapses occur
membranes of cells separated by narrow narrow gap
narrow gap spanned by clusters of connexins
connexin
special proteins that cluster together and span the narrow gap between cell membranes
connexon
six connexins combined
gap junction channel
two connexons (one from each cell) combine to form this
electrically coupled
cells connected by gap junctions
because electrical current in the form of ions can pass through channels
postsynaptic potential (PSP)
caused by current that flows across gap junction channels
when second neuron generates action potential, will induce PSP in first neuron
several occurring at same time may strongly excite a neuron
synaptic cleft
separates pre and post synaptic membranes at chemical synapses
presynaptic element
presynaptic side of the synapse
synaptic vesicles
dozens of small membrane enclosed spheres
in axon terminal
store neurotransmitter
secretory granules
larger vesicles
contain soluble protein that appears dark in the electron microscope
sometimes called large dense-core vesicles
membrane differentiation
dense accumulations of protein adjacent to and within the membranes on either side of the synaptic cleft