Sympathomimetics

Question 2

Cardiac muscle mainly has what type of receptors?

Answer 2

Beta 1

Question 3

Vascular smooth muscle has mainly what type of adrenergic receptors? (2)

Answer 3

alpha 1

beta 2

Question 4

Activates both alpha and beta receptors; higher affinity for beta

Answer 4

Epinephrine

Question 5

In general, alpha receptor activation causes ______.

Answer 5

vasoconstriction

Question 6

Beta receptor activation causes _______

Answer 6

vasodilation

Question 7

What receptor activates bronchial smooth muscle?

Answer 7

beta 2

Question 8

Selective beta 1 adrenergic receptor agonists (dobutamine) are useful for: (4)

Answer 8

treating shock
cardiac arrest
short term heart failure
performing stress tests

Question 9

What is a selective beta 2 adrenergic drug?

Answer 9

albuterol

Question 10

What adrenergic receptor type increases blood glucose in the liver?

Answer 10

beta 2

Question 11

What drug is a selective alpha 1 adrenergic receptor agonist?

Answer 11

phenylephrine

Question 12

What drug is a potent vasoconstrictor and acts as a decongestant by decreasing the volume of nasal mucosa?

Answer 12

phenylephrine (neosynephrine)

Question 13

What alpha 2 adrenergic receptor agonist is useful for hypertension and exerts hypotensive effects via CNS?

Answer 13

clonidine

Question 14

What drug is also used as an eyedrop solution to treat glaucome?

Answer 14

clonidine

Question 15

What drug inhibits monamine oxidase activity that increases the action of catecholamines by slowing catecholamine degradation and INDIRECTLY act as sympathomimetics?

Answer 15

phenelzine (Nardil)

Question 16

What MAO is useful in the treatment of depression, due to effects on CNS receptors…selegiline is currently a popular treatment for Parkinson’s Disease (enhances brain dopaminergic tone)?

Answer 16

phenelzine

Question 17

What drug has dangerous side effects include potentially fatal hypertensive crisis if combined improperly with other sympathomimetics or with foods rich in amines (wine, cheese, beer, chocolate, etc.)?

Answer 17

phenelzine

Question 18

What drugs bind to re-uptake transporters (NET) and vesicular transporters (VMAT) to cause reverse catecholamine transport…these drugs cause catecholamine release, and are therefore indirectly-acting sympathomimetic drugs?

Answer 18

methylphenidate (ritalin and amphetamine)

Question 19

What drug bind to transporters and cause catecholamine release…indirectly-acting sympathomimetics but does not efficiently cross the BBB and has few effects on the CNS?

Answer 19

Pseudo ephedrine

Question 20

What drug is an indirectly acting sympathomimetic and does act on the CNS?

Answer 20

methyphenidate

Question 21

What drug was used in cold formulas but was banned by the FDA and olympic committee?

Answer 21

pseudoephedrine