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General Pharmacology > Epilepsy / Local Anesthetics > Flashcards

Epilepsy / Local Anesthetics Flashcards

1
Q

What drugs:

decrease cortical activity → decrease seizure

teratogenic risks

A

epilepsy drugs

carbamazepine
ethosuximide
valproate
lorazepam

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2
Q

What epilepsy drug:

blocks Na
P450 inducer
diplopia
drowsiness
bipolar
partial complex

A

carbamazepine

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3
Q

What epilepsy drug:

partial complex
increase metabolism of other drugs
3A4*1B

A

carbemazepine

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4
Q

What epilepsy drug blocks Ca?

A

ethosuximide

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5
Q

What epilepsy drug:

no plasma binding
T1/2 = 40-60 hours

A

ethosuximide

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6
Q

What is the drug of choice for absence epilepsy?

A

ethosuximide

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7
Q

What drug:

blocks GABA and Na

A

valproate

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8
Q

What drug:

hepatotoxicity for children < 2
also for bipolar/migraines

A

valproate

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9
Q

What drug:

GABA inhibitor for treatment of epilepsy?

A

lorazepam

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10
Q

What is the degeneration of dopamine neurons?

A

Parkinson

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11
Q

What are the top treatments for Parkinson’s?

A

replace L-dopa with Sinemet

bromocryptine

selegiline

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12
Q

What is Sinemet?

A

L-dopa + carbidopa

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13
Q

What drug:

direct activation of dopamine receptors

A

bromocryptine

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14
Q

What drug:

blocks dopamine metabolism by MAO-B

A

selegiline

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15
Q

For LA, what type fibers are fastest to slowest to be affected?

A

Type C>B>A

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16
Q

What is the mechanism of action for LAs?

A

voltage gated Na blocker

17
Q

What is the order of blockade for the following senses/functions?

Touch

Pain

Deep pressure

Cold

Motor

A

Pain > Cold > Touch > Deep Pressure > Motor

18
Q

What class of LA is safer due to shorter half life?

A

esters

19
Q

What LA:

PABA blocks sufonamide
used for infiltration and regional anesthesia

A

Procaine

20
Q

What LA:

is used topically

A

benzocaine

short acting ester

21
Q

What LA is:

intermediate acting
risk of increased toxicity among esters

A

tetracaine

22
Q

What LA:

used for anesthesia for the nose/throat
cause mucous membrane irritation

A

tetracaine

23
Q

What LA:

replaced cocaine for cornea anesthesia b/c less irritating

A

proparacaine

24
Q

What LAs:

short-acting esters

A

procaine
benzocaine
tetracaine
proparacaine

25
Q

What LAs:

amides

A

lidocaine
bupivicaine

26
Q

What LA:

intermediate
use caution with amiodarone b/c causes arrhythmias
used for spinals

A

lidocaine

27
Q

What LA:

used for long, regional anesthesia
epidurals with opioids in labor
can also induce arrhythmias?

A

bupivicaine

General Pharmacology (24 decks)

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