Sufonamides, Trimethoprim, Quinolones Flashcards
What are anti-folate drugs? (2)
Sulfonamides
Trimethoprim
What inhibits the synthesis of dihydrofolic acid?
Sulfonamides
What inhibits the synthesis of tetrahydrofolate?
Trimethoprim
Dihydrofolate is inhibitor of what?
Dihydrofolic acid
Sulfonamides are:
bacteriostatic at _____ doses
bacteriocidal at _____ doses
______ is influenced by PABA analogs
lower (systemic)
higher (urinary)
Efficacy
What class is DOC for:
Prophylaxis of burn infections
Inflammatory disorders of the GI tract
sulfonamides
What class is 2nd line DOC for:
respiratory infections
uncomplicated UTI
sulfonamides
What are the sulfonamides? (2)
Sulfisoxazole
Sulfasalazine
What sulfonamide:
rapidly absorbed
UTI
systemic infection
Sulfisoxazole
What sulfonamide:
poorly absorbed
irritable bowel disorder
Sulfasalazine
What are adverse effects of sulfonamides? (6)
crystalluria
hypersensitivity
GI disturbances
hemolytic disturbances
hyperbilirubinemia
N/V
What acts synergistically with sulfonamide?
trimethoprim, (Co-trimoxazole), 1/10
Trimethoprim is a broad spectrum antibiotic. True or false?
True
What is DOC:
Urinary tract infections. Acute, chronic, recurrent
Chronic bacterial prostatitis
Pneumocystis carinii pneumonia in AIDS patients
Trimethoprim
What class of antibiotic is a DNA gyrase (topoisomerase II) inhibitor?
Quinolones
What are the fluoroquinolines? (4)
Cipro
Floxin
Levofloxacin
Gatifoxacin
Fluoroquinolones have an after-drug effect. True or false?
True
Fluoroquinolines are most active again most aerobic Gram + bacteria. True or false?
False, Gram -
Are the fluoroquinolones well tolerated and safe for pregnant women or children < 18 y/o?
Yes, well tolerated but not safe for preggo and <18 y/o.
What are drug interactions of quinolones? (4)
P450 inhibition, potentiate theophylline toxicity
Caffeine
NSAIDs
Divalent, trivalent cations
What fluoroquinolines inhibit P450? (2)
Cipro
ofloxacin (Floxin)
What fluoroquinoline is also known as inhalational anthrax?
Cipro
