Sympathomimetics

Question 1

constriction of blood vessels

Answer 1

alpha 1

lesser extent alpha 2

Question 2

mydriasis

Answer 2

alpha 1

• iris radial muscle
• dilation of pupil

Question 3

contraction of spleen

Answer 3

alpha 1

Question 4

contraction of uterus

Answer 4

alpha 1

Question 5

constrict sphincter of bladder

Answer 5

alpha 1

Question 6

liver glycogenolysis

Answer 6

alpha 1

Question 7

ejaculation

Answer 7

alpha 1

Question 8

insulin release inhibition

Answer 8

alpha 2

Question 9

relax intestinal smooth muscle

Answer 9

alpha 2

Question 10

increased contraction and rate of heart

Answer 10

beta 1

Question 11

increased renin release

Answer 11

beta 1

Question 12

relax bronchioles

Answer 12

beta 2

Question 13

relax uterus

Answer 13

beta 2

Question 14

relax vascular smooth m in certain blood vessels - skeletal m, coronaries, mesenteric

Answer 14

beta 2

Question 15

glycogenolysis

Answer 15

beta 2

Question 16

lipolysis

Answer 16

beta 1

Question 17

insulin release stimulation

Answer 17

beta 2

Question 18

relax detrusor muscle

Answer 18

beta 2

to store urine

voiding - contracts

Question 19

relax intestinal smooth m

Answer 19

beta 2

Question 20

structure of catecholamines

Answer 20

catechol and ethylamine with different side groups

Question 21

tyramine

Answer 21

catecholamine releasing agent

blocked by cocaine

Question 22

action of beta receptors

Answer 22

stimulate adenylyl cyclase

Question 23

action of alpha receptors

Answer 23

inhibit adenylyl cyclase

Question 24

action of epinephrine

Answer 24

increase heart rate and contractility

low dose - beta 2 skeletal m vessel relaxation
high dose - alpha 1 skeletal m vessel constriction

Question 25

epinephrine on pancreas

Answer 25

alpha 2 > beta 2 | -block release of insulin

Question 26

prolonged local anesthetics

Answer 26

when mixed with epinephrine

Question 27

anaphylactic shock

Answer 27

treat with IM injection of epinephrine efficacy on alpha 1 and beta 2 receptors

Question 28

contraindications for epinephrine

Answer 28

``` HTN shock hyperthyroid angina pectoris asthmatics with degenerative heart disease ```

Question 29

vasculature alpha vs. beta

Answer 29

beta 2 - relax | alpha 1 - constrict

Question 30

beta receptor antagonists in eye

Answer 30

decrease aqueous humor production

Question 31

alpha receptor agonists in eye

Answer 31

mydriasis | also - increase aqueous humor outflow

Question 32

CV and epinephrine

Answer 32

beta1, beta2, alpha effects increased systolic (beta1) decreased TPR and decreased diastolic (beta2 skeletal m. dilation overcomes alpha1 constriction)

Question 33

CV and norepinephrine

Answer 33

beta1, alpha effects no beta2** increased TPR and diastolic (no beta2 on skeletal m. dilation, only alpha1 constriction effects) increased systolic BP and MAP stimulant on rate, but overcome by reflex baroreceptor vagal output

Question 34

CV and isoproterenol

Answer 34

beta1, beta 2 effects no alpha** increased HR and force of contraction (beta1) decreased TPR (beta2 in skeletal m vasodilation) increased systolic decreased diastolic

Question 35

dopamine

Answer 35

beta1 agonist D1 agonist high dose - alpha1 agonist -will override dopaminergic effects

Question 36

effect of dopamine

Answer 36

increased HR and contractility - beta1 increased blood flow in renal, coronary, splanchnic - D1

Question 37

higher dose of dopamine

Answer 37

alpha1 receptor activation | -overcomes vasodilatory effects

Question 38

femoldopam

Answer 38

D1 agonist Tx for hypertension

Question 39

bromocroptine

Answer 39

D2 agonist Tx for parkinsons or prolactinemia

Question 40

dobutamine

Answer 40

beta1 agonist weak increase in contractility and HR

Question 41

clinical use of dobutamine

Answer 41

increased CO in patients with cardiogenic shock with decreased occurence of arrythmia

Question 42

phenylephrine

Answer 42

alpha-1 agonists vascular constriction - reflex bradycardia - can be blocked with atropine

Question 43

methoxamine

Answer 43

alpha 1 agonist similar to phenylephrine

Question 44

midodrine

Answer 44

alpha 1 agonist Tx for disabling orthostatic hyoptension

Question 45

beta 2 agonists

Answer 45

10x greater selectivity for beta2 than beta1 so beta1 can be stimulated at high dose

Question 46

albuterol

Answer 46

beta 2 agonist for bronchial asthma

Question 47

salmeterol

Answer 47

beta 2 agonist long lasting nighttime asthma

Question 48

formoterol

Answer 48

beta 2 agonist same as salmeterol long acting

Question 49

metaproterenol

Answer 49

beta 2 agonist relax bronchial smooth muscle side effects: nervous, weak, palpitations, N/V

Question 50

terbutaline

Answer 50

beta 2 agonist used orally and as aerosol

Question 51

ritodrine

Answer 51

beta 2 agonist for delayed delivery

Question 52

amphetamines

Answer 52

release NE from adrenergic nerve ending AND inhibit NE reuptake CNS stimulant

Question 53

adderall

Answer 53

amphetamine | for ADHD

Question 54

dexedrine

Answer 54

amphetamine

Question 55

benzedrine

Answer 55

amphetamine

Question 56

Tx for narcolepsy

Answer 56

amphetamine

Question 57

Tx for obesity

Answer 57

amphetamine

Question 58

Tx for ADHD

Answer 58

amphetamine

Question 59

amphetamine poisoning

Answer 59

weak bases acidification of urine will decrease reabsorption

Question 60

mixed action

Answer 60

ephedrine

Question 61

ephedrine

Answer 61

beta agonist AND indirect NE release

Question 62

pseudoephedrine

Answer 62

OTC cough and cold | -now illegal bc can be used to make methamphetamine

Question 63

nasal decongestants

Answer 63

alpha 1 vasoconstriction

Question 64

naphazoline

Answer 64

nasal decongestant

Question 65

tetrahydrozoline

Answer 65

nasal decongestant

Question 66

xylometazoline

Answer 66

nasal decongestant

Question 67

oxymetazoline

Answer 67

nasal decongestant

Question 68

hydroxyamphetamine

Answer 68

similar to ephedrine | -but decreased CNS activity due to more polarity