Review II Flashcards by Matt Stanton | Brainscape

Q

pupil dilation

A

alpha1 - radial m. - sympathetic

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Q

insulin release

A

inhibition - alpha2

stimulation - beta2

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Q

renin release

A

beta1

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Q

cardiac M

A

M2

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Q

botulinum

A

inhibit ACh release

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Q

muscarine

A

quaternary amine
-mushrooms
enter the brain

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Q

pilocarpine

A

mAChR agonist

tertiary - readily absorbed

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Q

cevilemine

A

mAChR agonist

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Q

bethanechol

A

quaternary - poor absorption - little CNS effects

mAChR agonist

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Q

increased salivary secretion

A

pilocarpine and cevilemine

both mAChR agonists

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Q

varenicline

A

alpha4 beta2 nAChR agonist

smoking cessation

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Q

smoking cessation

A

varenicline

nAChR agonist

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Q

closed angle glaucoma

A

pilocarpine and pysostigmine

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Q

urinary retention

A

bethanechol

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Q

post operative ileus

A

bethanechol

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Q

methacholine

A

to Dx bronchial airway hyperreactivity

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Q

edrophonium

A

reversible inhibition of AChE

quaternary ammonium

Q

physostigmine

A

CNS effects

Q

neostigmine

A

low CNS effects
AChE inhibitor

also has effects at NMJ

Q

pralidoxime

A

AChE reactivator

Q

organophosphate poisoning

A

pralidoxime

Q

closed angle glaucoma

A

physostigmine - AChE inhibitor

pilocarpine - mAChR agonist

Q

anticholinergic intoxication

A

Tx - with physostigmine - AChE inhibitor

crosses BBB

Q

cholinergic poisoning

A

atropine and pralidoxime

atropine - mAChR antagonist
pralidoxime - regenerate AChE

Q

prophylaxis for AChE inhibitor poisoning

A

pyridostigmine

-reduces incapacitation and mortality

Q

atropine

A

mAChR antagonist

-works in CNS

Q

ipratropium

A

mAChR antagonist

peripheral affects
quaternary

Q

motion sickness

A

scopolamine

M1 antagonist

Q

gastric effects of atropine

A

only at high doses

Q

parkinsons tremor

A

Tx - antimuscarinic

Q

surgical manipulation of organs

A

atropine

- to block vagal response

Q

COPD

A

ipratropum and tiotropium

blocks PS bronchoconstriction

Q

travellers diarrhea

A

atropine combined with opiod antidiarrheal

Q

oxybutynin

A

m3 selective antagonist

reduce urinary frequency

Q

reduce urinary frequency

A

oxybutynin - M3 selective antagonist

Q

atropine poisoning

A

dry as a bone, blind as a bat, red as a beet, mad as a hatter, hot as a hare

Tx - cholinesterase inhibitors - physostigmine

Q

mecamylamine

A

ganglion blocker

Q

ganglion blocking drug effects

A

enhance sympathetic tone

dilation of pupil (bc PS dominates)

Q

rapid onset mushroom poisoning

A

Tx atropine

Q

M1, 3, 5

A

excitatory

Q

M2, 4

A

inhibitory