Review II

Question 1

pupil dilation

Answer 1

alpha1 - radial m. - sympathetic

Question 2

insulin release

Answer 2

inhibition - alpha2

stimulation - beta2

Question 3

renin release

Answer 3

beta1

Question 4

cardiac M

Answer 4

M2

Question 5

botulinum

Answer 5

inhibit ACh release

Question 6

muscarine

Answer 6

quaternary amine
-mushrooms
enter the brain

Question 7

pilocarpine

Answer 7

mAChR agonist

tertiary - readily absorbed

Question 8

cevilemine

Answer 8

mAChR agonist

Question 9

bethanechol

Answer 9

quaternary - poor absorption - little CNS effects

mAChR agonist

Question 10

increased salivary secretion

Answer 10

pilocarpine and cevilemine

both mAChR agonists

Question 11

varenicline

Answer 11

alpha4 beta2 nAChR agonist

smoking cessation

Question 12

smoking cessation

Answer 12

varenicline

nAChR agonist

Question 13

closed angle glaucoma

Answer 13

pilocarpine and pysostigmine

Question 14

urinary retention

Answer 14

bethanechol

Question 15

post operative ileus

Answer 15

bethanechol

Question 16

methacholine

Answer 16

to Dx bronchial airway hyperreactivity

Question 17

edrophonium

Answer 17

reversible inhibition of AChE

quaternary ammonium

Question 18

physostigmine

Answer 18

CNS effects

Question 19

neostigmine

Answer 19

low CNS effects
AChE inhibitor

also has effects at NMJ

Question 20

pralidoxime

Answer 20

AChE reactivator

Question 21

organophosphate poisoning

Answer 21

pralidoxime

Question 22

closed angle glaucoma

Answer 22

physostigmine - AChE inhibitor

pilocarpine - mAChR agonist

Question 23

anticholinergic intoxication

Answer 23

Tx - with physostigmine - AChE inhibitor

crosses BBB

Question 24

cholinergic poisoning

Answer 24

atropine and pralidoxime

atropine - mAChR antagonist
pralidoxime - regenerate AChE

Question 25

prophylaxis for AChE inhibitor poisoning

Answer 25

pyridostigmine | -reduces incapacitation and mortality

Question 26

atropine

Answer 26

mAChR antagonist | -works in CNS

Question 27

ipratropium

Answer 27

mAChR antagonist - peripheral affects - quaternary

Question 28

motion sickness

Answer 28

scopolamine M1 antagonist

Question 29

gastric effects of atropine

Answer 29

only at high doses

Question 30

parkinsons tremor

Answer 30

Tx - antimuscarinic

Question 31

surgical manipulation of organs

Answer 31

atropine | - to block vagal response

Question 32

COPD

Answer 32

ipratropum and tiotropium blocks PS bronchoconstriction

Question 33

travellers diarrhea

Answer 33

atropine combined with opiod antidiarrheal

Question 34

oxybutynin

Answer 34

m3 selective antagonist reduce urinary frequency

Question 35

reduce urinary frequency

Answer 35

oxybutynin - M3 selective antagonist

Question 36

atropine poisoning

Answer 36

dry as a bone, blind as a bat, red as a beet, mad as a hatter, hot as a hare Tx - cholinesterase inhibitors - physostigmine

Question 37

mecamylamine

Answer 37

ganglion blocker

Question 38

ganglion blocking drug effects

Answer 38

enhance sympathetic tone dilation of pupil (bc PS dominates)

Question 39

rapid onset mushroom poisoning

Answer 39

Tx atropine

Question 40

M1, 3, 5

Answer 40

excitatory

Question 41

M2, 4

Answer 41

inhibitory