Adrenergic Antagonists

Question 1

phenoxybenzamine

Answer 1

alpha1 and alpha2 antagonist
-covalent binding

a1>a2

t1/2 - 24 hours

vasodilation and tachycardia

Question 2

pheochromocytoma

Answer 2

tumor of adrenal medulla releasing NE and E

Question 3

Tx for pheochromocytoma

Answer 3

pre-op management - phenoxybenzamine and beta blocker

Question 4

phentolamine

Answer 4

alpha1 and alpha 2 antagonist

increases HCl in stomach

decreased BP leads to reflex tachycardia

stimulate GI motility and release of HCl

Question 5

acute hypertensive emergency

Answer 5

phentolamine

accompany surgical manipulation of pheochromocytoma

BP maintenance

Question 6

tolazoline

Answer 6

alpha1 and alpha2 antagonist

treat persistant vasoconstriction and HTN of newborn

Question 7

yohimbine

Answer 7

selective alpha2 and 5-HT antagonist

claim - improve male sexual function

Question 8

haloperidol

Answer 8

alpha1 and dopamine antagonist

Question 9

chlorpromazine

Answer 9

alpha1 and dopamine antagonist

Question 10

ergot alkaloids

Answer 10

in rye fungus

ingestion - gangrene, convulsions, spontaneous abortions

alpha antagonist

Question 11

ergotamine

Answer 11

Tx for migraine headaches

alpha antagonist

Question 12

prazosin

Answer 12

alpha1&raquo_space;»alpha2 antagonist

selective alpha1 antagonist

decreased reflex tachycardia - bc leaves the alpha2 inhibition on NE release from nerve endings

Question 13

terazosin

Answer 13

alpha1 selective antagonist

Tx of HTN and BPH

Question 14

doxazosin

Answer 14

alpha1 selective antagonist

Tx of HTN and BPH

Question 15

tamulosin

Answer 15

selective alpha1A antagonist

Tx of BPH
-with less reflex tachycardia

Question 16

benign prostatic hypertrophy

Answer 16

Tx is reversal of smooth muscle contraction in enlarged prostate and bladder base

use alpha1 selective antagonist

Question 17

propanolol

Answer 17

beta1 and beta2 antagonist

lipid soluble

decrease HR and CO

acute vasodilation
chronic decrease in TPR

blocks bronchodilation

blocks lipolysis and glycogenolysis

Question 18

high dose propanolol

Answer 18

local anesthetic like membrane stabilizing effect

Question 19

contraindication for propanolol

Answer 19

asthmatic

don’t want the beta2 antagonist effect of propanolol

Question 20

Tx of pheochromocytoma

Answer 20

propanolol and alpha antagonist

Question 21

Tx of angina pectoris

Answer 21

propanolol

Question 22

Tx of HTN

Answer 22

propanolol

Question 23

Tx for stage fright

Answer 23

propanolol

Question 24

after myocardial infarction

Answer 24

beta antagonist
ex. propanolol

shown to decrease arrhythmias and recurrent ischemia

Question 25

use propanolol with caution

Answer 25

insulin dependent diabetics | -especially pancreatectomized

Question 26

sudden withdrawal of propanolol

Answer 26

angina attack rebound HTN MI **withdraw slowly by reducing disage

Question 27

contraindications for propanolol

Answer 27

heart failure, cardiogenic shock, 2nd or 3rd degree AV block asthma

Question 28

nadolol

Answer 28

beta antagonists longer acting than propanolol Tx for angina and HTN once a day dosage

Question 29

timolol

Answer 29

beta antagonist 5-10x more potent than propanolol Tx of HTN and glaucoma

Question 30

timolol maleate

Answer 30

ophthalmic solution -reduces aqueous humor prodiction in glaucoma

Question 31

metoprolol

Answer 31

selective beta1 antagonist Tx for HTN widely used**

Question 32

atenolol

Answer 32

beta1 antagonist lessens risk of bronchospasm

Question 33

labetalol

Answer 33

alpha1 and beta antagonist Tx for HTN and pheochromocytoma

Question 34

carvedilol

Answer 34

beta antagonist also some alpha1 antagonist reduce mortality in patients with CHF

Question 35

pindolol

Answer 35

partial beta2 agonist activity HTN and angina Tx

Question 36

acebutolol

Answer 36

beta1 partial agonist HTN and dysrhythmias

Question 37

betaxolol

Answer 37

beta1 selective antagonist glaucoma and HTN Tx

Question 38

esmolol

Answer 38

short acting beta1 antagonist clinical use - prophylactic for perioperative tachycardia and HTN, as well as electroconvulsive therapy

Question 39

Tx for pheochromocytoma

Answer 39

phentolamine and phenoxybenzamine beta antagonist used after alpha blockade established