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RENAL II Exam 1 > Adrenergic Antagonists > Flashcards

Adrenergic Antagonists Flashcards

1
Q

phenoxybenzamine

A

alpha1 and alpha2 antagonist
-covalent binding

a1>a2

t1/2 - 24 hours

vasodilation and tachycardia

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2
Q

pheochromocytoma

A

tumor of adrenal medulla releasing NE and E

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3
Q

Tx for pheochromocytoma

A

pre-op management - phenoxybenzamine and beta blocker

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4
Q

phentolamine

A

alpha1 and alpha 2 antagonist

increases HCl in stomach

decreased BP leads to reflex tachycardia

stimulate GI motility and release of HCl

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5
Q

acute hypertensive emergency

A

phentolamine

accompany surgical manipulation of pheochromocytoma

BP maintenance

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6
Q

tolazoline

A

alpha1 and alpha2 antagonist

treat persistant vasoconstriction and HTN of newborn

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7
Q

yohimbine

A

selective alpha2 and 5-HT antagonist

claim - improve male sexual function

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8
Q

haloperidol

A

alpha1 and dopamine antagonist

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9
Q

chlorpromazine

A

alpha1 and dopamine antagonist

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10
Q

ergot alkaloids

A

in rye fungus

ingestion - gangrene, convulsions, spontaneous abortions

alpha antagonist

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11
Q

ergotamine

A

Tx for migraine headaches

alpha antagonist

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12
Q

prazosin

A

alpha1&raquo_space;»alpha2 antagonist

selective alpha1 antagonist

decreased reflex tachycardia - bc leaves the alpha2 inhibition on NE release from nerve endings

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13
Q

terazosin

A

alpha1 selective antagonist

Tx of HTN and BPH

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14
Q

doxazosin

A

alpha1 selective antagonist

Tx of HTN and BPH

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15
Q

tamulosin

A

selective alpha1A antagonist

Tx of BPH
-with less reflex tachycardia

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16
Q

benign prostatic hypertrophy

A

Tx is reversal of smooth muscle contraction in enlarged prostate and bladder base

use alpha1 selective antagonist

17
Q

propanolol

A

beta1 and beta2 antagonist

lipid soluble

decrease HR and CO

acute vasodilation
chronic decrease in TPR

blocks bronchodilation

blocks lipolysis and glycogenolysis

18
Q

high dose propanolol

A

local anesthetic like membrane stabilizing effect

19
Q

contraindication for propanolol

A

asthmatic

don’t want the beta2 antagonist effect of propanolol

20
Q

Tx of pheochromocytoma

A

propanolol and alpha antagonist

21
Q

Tx of angina pectoris

A

propanolol

22
Q

Tx of HTN

A

propanolol

23
Q

Tx for stage fright

A

propanolol

24
Q

after myocardial infarction

A

beta antagonist
ex. propanolol

shown to decrease arrhythmias and recurrent ischemia

25
Q

use propanolol with caution

A

insulin dependent diabetics

-especially pancreatectomized

26
Q

sudden withdrawal of propanolol

A

angina attack
rebound HTN
MI

**withdraw slowly by reducing disage

27
Q

contraindications for propanolol

A

heart failure, cardiogenic shock, 2nd or 3rd degree AV block

asthma

28
Q

nadolol

A

beta antagonists

longer acting than propanolol

Tx for angina and HTN

once a day dosage

29
Q

timolol

A

beta antagonist

5-10x more potent than propanolol

Tx of HTN and glaucoma

30
Q

timolol maleate

A

ophthalmic solution

-reduces aqueous humor prodiction in glaucoma

31
Q

metoprolol

A

selective beta1 antagonist

Tx for HTN

widely used**

32
Q

atenolol

A

beta1 antagonist

lessens risk of bronchospasm

33
Q

labetalol

A

alpha1 and beta antagonist

Tx for HTN and pheochromocytoma

34
Q

carvedilol

A

beta antagonist
also some alpha1 antagonist

reduce mortality in patients with CHF

35
Q

pindolol

A

partial beta2 agonist activity

HTN and angina Tx

36
Q

acebutolol

A

beta1 partial agonist

HTN and dysrhythmias

37
Q

betaxolol

A

beta1 selective antagonist

glaucoma and HTN Tx

38
Q

esmolol

A

short acting beta1 antagonist

clinical use - prophylactic for perioperative tachycardia and HTN, as well as electroconvulsive therapy

39
Q

Tx for pheochromocytoma

A

phentolamine and phenoxybenzamine

beta antagonist used after alpha blockade established

RENAL II Exam 1 (9 decks)

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