SWI/SNF Flashcards
1
Q
How do studies show that SWI/SNF is involved in brain development
A
1)Brg1 was found to be critical for progenitor growth and was associated with the inclusion of specific subunits within the complex.
The switch from proliferation to terminal differentiation was associated with change from Brg/Brm interactions with Baf45a/53a subunits in progenitor cells to the use of Baf45b/Baf45c/Baf53b(Lessard et al, 2007)
2)Competition between Baf155 and Baf170 subunits was shown to mediate intermediate progenitor cell production and late born cortical neuron output
3) Mutations in genes encoding BRG1(SMARCA4), BRM(SMARCA2),BAF47(SMARCB1) and BAF57(SMARCE1) have been implicated in ID disorders
