iPSCs And ESCs Flashcards
1
Q
How have PSCs been instrumental in advancing human disease modeling using patient derived iPSCs and genome editing of ESCs and iPSCs
A
IPSCs can be generated from patient cells and differentiated into affected cell types to recapitulate disease phenotypes in vitro, to identifying novel pathological mechanisms and to identify therapeutic targets or potential therapeutics to modify disease progression
The field is now poised to transform drug discovery and development using PSC-derived primary human disease cells for high throughput screens for disease modifying drugs, drug toxicity analysis and developing sophisticated humanize mouse models of disease to test therapeutics.
