Surgery- SIRS Flashcards

1
Q

Best characterized DAMP in the context of injury associated inflammation

A

High motility Group B1 (HMGB1)

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2
Q

How does the CNS sense inflammation?

A

DAMPs and inflammatory molecules

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3
Q

The pro inflammatory response is countered by what mechanism?

A

HPA axis and release of glucocorticoids

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4
Q

What will manifest in the inflammatory stimuli in the CNS

A

increased sleep, lethargy, reduced appetite, fever

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5
Q

Peripheral inflammation and tissue damage can also be signaled to the brain via?

A

Vagus nerve

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6
Q

Vagal stimulation will result in the activation of B2 adrenergic receptors that will release

A

Acetylcholine

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7
Q

What does the Ach do to regulate the pro inflammatory response?

A

Targets the alpha-7 nicotinic Ach receptor

  1. Blocks cell activation
  2. Inhibits cytokine production
  3. Shifting of microphage toward an M2 anti-inflammatory
  4. Inhibits intracellular binding
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8
Q

Two principles in the neuroendocrine pathways that orchestrate the host response

A

HPA

Sympathetic nervous system

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9
Q

Sympathetic nervous system releases what hormones?

A

Catecholamines, norepi, epi

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10
Q

Major glucocorticoid in humans and is essential for survival during significant physiologic stress

A

Cortisol

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