Surgery- SIRS Flashcards
Best characterized DAMP in the context of injury associated inflammation
High motility Group B1 (HMGB1)
How does the CNS sense inflammation?
DAMPs and inflammatory molecules
The pro inflammatory response is countered by what mechanism?
HPA axis and release of glucocorticoids
What will manifest in the inflammatory stimuli in the CNS
increased sleep, lethargy, reduced appetite, fever
Peripheral inflammation and tissue damage can also be signaled to the brain via?
Vagus nerve
Vagal stimulation will result in the activation of B2 adrenergic receptors that will release
Acetylcholine
What does the Ach do to regulate the pro inflammatory response?
Targets the alpha-7 nicotinic Ach receptor
- Blocks cell activation
- Inhibits cytokine production
- Shifting of microphage toward an M2 anti-inflammatory
- Inhibits intracellular binding
Two principles in the neuroendocrine pathways that orchestrate the host response
HPA
Sympathetic nervous system
Sympathetic nervous system releases what hormones?
Catecholamines, norepi, epi
Major glucocorticoid in humans and is essential for survival during significant physiologic stress
Cortisol