Pharma-inflam and Gout/blood prod

Question 1

All NSAIDS are weak organic acids EXCEPT

Answer 1

Nebumetone

Question 2

MOA of methotrexate

Answer 2

Inhibition of amino-imidazolecarboxamide ribonucleotide (AICAR)
Inhibition of thymidylate synthass
Inhibits dihydrofolate reductase

Question 3

Primary treatment for acute gout

Answer 3

Colchicine

Question 4

Adverse effects of colchicine

Answer 4

Inhibition of tubulin polymerization and cell mitosis

Question 5

Prevents attacks of acute mediterranean fever

Answer 5

Colchicine

Question 6

Treatment for chronic gout

Answer 6

Probenecid

Sulfinpyrazone

Question 7

Aspirin is contraindicated in children because it causes

Answer 7

Reye’s syndrome

Question 8

Has a mechanism of action in which it inhibits the T cells. CTLA4 binds to CD80 and CD86 on APCs

Answer 8

Abatacept

Question 9

Targets CD20 B lymphocytes and readily depletes peripheral B cells

Answer 9

Rituximab

Question 10

Inhibits IL-6 mediated signaling by binding soluble membrane bound IL-6 receptors

Answer 10

Tocilizumab

Question 11

Anti TNF alpha drugs

Answer 11

Adalimumab
Infliximab
Etanercept
Certolizumab
Golimumab
Tofacitinib

Question 12

Complexes with soluble TNF-a preventing interaction with p55 and p75 receptors which results in the down regulation of macrophage and T-cell function

Answer 12

Adalimumab

Question 13

COX-2 selective inhibitors

Answer 13

Celecoxib
Meloxicam
Etoricoxib
Valdecoxib
Rofecoxib

Question 14

Nonselective COX inhibitors

Answer 14

Ibuprofen
Flurbiprofen
Diclofenac
Etodolac
Piroxicam
Nabumetone
Indomethacin
Meclofenamic acid
Naproxen
Oxaprozin
Sulindac

Question 15

effective in closing patent ductus arteriosus in preterm infants

Answer 15

Both oral and IV ibuprofen

Question 16

Ibuprofen is contraindicated in

Answer 16

Nasal polyps
Angioedema
Bronchospastic reactivity with aspirin

Question 17

For osteoarthritis and rheumatoid arthritis

Answer 17

Etodolac

Question 18

High concentrations of piroxicam could

Answer 18

Inhibit polymorphonuclear leukocyte migration
Decrease oxygen radical production
Inhibits lymphocyte function

Question 19

Has an adverse effect of steven johnson syndrome

Answer 19

Ethosuximide and sulindac

Question 20

First line of DMARD for treating RA

Answer 20

Methotrexate

Question 21

Nonbiologic DMARDS that has a MOA of attachment of alkyl groups to DNA bases resulting in the fragmentation of DNA preventing synthesis and RNA transcription

Answer 21

Chlorambucil

Question 22

Chlorambucil is for the treatment of

Answer 22

Chronic lymphatic leukemia
Childhood minimal-change nephrotic syndrome
Malignant lymphomas

Question 23

Overdosage symptoms of sodium aurathiomalate

Answer 23

Pruritus
Dermatitis
Stomatitis

Question 24

Treatment for excess heparin

Answer 24

Protamine sulfate

Question 25

Drug of choice for heparin induced thrombocytopenia

Answer 25

Argatroban

Question 26

Drug of choice for cerebral stroke

Answer 26

Dabigatran etexilate mesylate PO

Question 27

Recombinant human granulocyte colony stimulating factor

Answer 27

Filgrastim
Lenograstim
Pegfilgrastim

Question 28

Alternative drug in place of rHuG-CSF; capillary leak syndrome

Answer 28

Sargramostim

Question 29

Drug of choice for bone marrow depression or aplastic anemia

Answer 29

Pegfilgastrim

Question 30

Drug of choice for Idiopathic thrombocytopenic purpura

Answer 30

Thrombopoietin

Question 31

Drug of choice for bone marrow induced thrombocytopenia

Answer 31

Romiplostim (Thrombopoietin like)