Surg 126--Chapter 8 Flashcards
Chemicals released by endocrine glands into the bloodstream.
Hormones
How do hormones maintain homeostasis?
By altering the activities of specific target cells.
What functions are regulated by hormones?
- reproduction
- growth and development
- metabolism
Works with the nervous system to relay messages to maintain homeostasis.
endocrine system
How are hormones classified?
steroid or nonsteroid
Steroid hormones are derived from _____.
cholesterol
In cellular mitochondria, enzymes convert cholesterol into _____, which is not a hormone, but the immediate precursor molecule to the synthesis of all steroid hormones.
pregnenolone
Steroid hormones are classified as:
- glucocorticoids (cortisol)
- mineralocorticoids (aldosterone)
- estrogens
- progestogens (progesterone)
- androgens (male sex hormones, testosterone)
Nonsteroid hormones are synthesized from _____.
amino acids
The simplest hormones are _____, derived from amino acids.
amines
Nonsteroid, amine hormones include:
- epinephrine
- norepinephrine
- throxine
- triiodothyronine
Hormones made of short chains of amino acids are called _____.
peptide hormones
Nonsteroid, peptide hormones include:
antidiuretic hormone (ADH) and oxytocin
Longer, folded chains of amino acids are called _____.
protein hormones
Nonsteroid, protein hormones include:
- growth hormone (GH)
- parathyroid hormone (PTH)
- insulin
- glucagon
Hypothalamus hormones:
Production of ADH, oxytocin and regulatory hormones
Pituitary hormones:
Anterior pituitary: -adrenocorticotropic hormone (ACTH) -thyroid stimulating hormone (TSH) -growth hormone (GH) -prolactin (PRL) -follicle-stimulating hormone (FSH) -luteinizing hormone (LH) -MSH Posterior pituitary: -release of oxytocin and vasopressin (ADH)
Thyroid hormones:
- Thyroxin (T4)
- Triiodothyronine (T3)
- Calcitonin (CT)
Thymus hormones:
Thymosins
atrophies during adulthood
Adrenal hormones:
Medulla: -Epinephrine (E) -Norepinephrine (NE) Cortex: -Cortisol -Corticosterone -Aldosterone -Androgens
Pineal glands:
-Melatonin
Parathyroid hormones:
-Parathyroid hormones (PTH)
Heart hormones:
-Atrial natriuretic peptide (ANP)
Kidney hormones:
- Erythropoietin (EPO)
- Calcitrol
Digestive tract hormones:
-Numerous hormones
Pancreatic Islet hormones:
- Insulin
- Glucagon
Gondad hormones:
Ovaries (Female) -Estrogens -Progestins -Inhibin Testes (Male) -Androgens -Testosterone -Inhibin
Know as the “master gland,” has a vital role in the reproduction and growth, and it regulates the function of the renal system and thyroid gland.
Pituitary gland
The pituitary gland is connected to the hypothalamus by a stalk called the _____.
infundibulum
It is divided into two lobes–the anterior or _____ and the posterior or _____.
- adenohypophysis
- neurohypophysis
Stimulates the uterine contractions necessary for normal labor and delivery.
oxytocin
Oxytocin is available as:
- oxytocin
- pitocin
- syntocinon
It is important to avoid confusion of _____ and _____.
Pitocin and Pitressin
A vascular structure consisting of two lobes joined by an isthmus.
thyroid gland
The largest of the endocrine glands, the _____ is located below the larynx, on both sides of the trachea in the anterior neck.
thyroid
What sets the rate of body metabolism?
thyroid gland
Lack of thyroid hormones slows _____.
metabolism
What is the most common cause of hyperthyroidism?
Graves disease
An autoimmune disorder in which the body attacks the thyroid gland causing it to over-produce thyroxine.
Graves disease
What hormones are regulated by thyroid stimulating hormone (TSH) (thyrotopin), which is produced in the anterior lobe of the pituitary gland?
- Thyroxin (T4)
- Triiodothyronine (T3)
What hormones are essential for normal growth and development, and help regulate metabolism of carbohydrates, lipids, and proteins?
- Thyroxin (T4)
- Triiodothyronine (T3)
Require iodine salts for production.
- Thyroxin (T4)
- Triiodothyronine (T3)
What hormone helps to control calcium and phosphate concentrations in the blood, and is regulated by blood levels of these ions
Calcitonin
Affects calcium and phosphate levels by inhibiting the rate of release from bone, increasing the rate of incorporation of these ions into bone, and increasing excretion of these ions by the kidneys.
Calcitonin
What is a common antithyroid medication?
Tapazole
Small, yellowish-brown ovals, approximately 6mm in length, and frequently covered with adipose tissue.
parathyroid gland
Usually found embedded in the posterior surface of the thyroid gland.
parathyroid gland
The number of parathyroid glands may vary from _____ to ______, with 90% of the patients having _____; _____ on each side of the thyroid gland.
two to six
four
two
Parathyroid gland produces _____, which monitors circulating concentrations of calcium ions in the blood.
parathyroid hormone (PTH)
Parathyroid hormone has four major functions:
- to stimulate osteoclasts
- to inhibit osteoblasts
- to enhance the reabsorption of calcium deposition in the bone
- to stimulate the formation and secretion of calcitriol at the kidneys
PTH stimulates osteoclasts which accelerates mineral turnover and _____.
the release of calcium from bone
PTH inhibits osteoblasts reducing the rate of _____.
calcium deposition in bone
PTH enhances the reabsorption of calcium at the kindeys, reducing its loss via _____.
urine
PTH stimulates the formation and secretion of calcitriol at the kidneys for enhancement of calcium and phosphate absorption by the _____.
digestive tract
Inadequate amounts of PTH result in low calcium concentrations and _____.
hypoparathyroidism
Hypoparathyroidism can cause a condition called _____.
tetany
Characterized by prolonged muscle spasms involving the face and extremities.
tetany
Parathyroid hormone includes _____.
teriparatide (Forteo)
True or False: Parathyroid hormones are not administered in surgery from the sterile back table.
True
What causes hyperparathyroidism?
calcium concentrations become too high
Bones can grow thin and brittle, skeletal muscles weaken, and the CNS is depresses.
hypepararthyroidism
Highly vascular, pyramid-shaped glands positioned on top of each kidney.
Adrenal glands
What are the parts of the adrenal glands.
- central portion
- medulla
- cortex
Produces, stores, and secretes the hormones epinephrine (adrenaline), norepinephrine (noradrenaline), and dopamine, collectively called catecholamines.
Adrenal medulla
Work with the sympathetic nervous system to prepare the body for the fight-or-flight response to stress.
epinephrine and norepinephrine
Effects of these hormones include increased heart rate, increased force of cardiac muscle contraction, vasoconstriction, elevated blood pressure, increased respiratory rate, and decreased digestive system activity.
epinephrine and norepinephrine
What are the two major groups of adrenal cortex hormones?
glucocorticoids and mineralcorticoids (steroids)
What is the most important mineralcorticoid?
aldosterone
Maintains homeostatic levels of sodium and potassium in the blood.
aldosterone
Used alone or in combination to reduce or inhibit the inflammatory response after surgical procedures such as shoulder arthroscopy or cataract extraction.
glucocorticoids
Used medically to help prevent rejection of donated organs, to reduce the inflammatory response in patients with arthritis, and with aldosterone as replacement therapy for Addison’s disease.
glucocorticoids
Used for the treatment of autoimmune disorders, to suppress hypersensitivity reactions, and to alleviate cerebral edema.
glucocorticoids
Glucocorticoids administered for diseases such as arthritis are used as _____.
palliatives
Drugs that relieve symptoms, but they do not cure the condition or disease.
palliative drugs
How are glucocorticoids administered?
- orally
- topically
- intramuscularly
- intraarticularly
- IV
- inhalation
Glucocorticoids may be _____ or _____ depending on the agent used.
long- or short-acting
Naturally occurring steroids:
- cortisone
- hydrocortisone
- aldosterone
Synthetic steroid hormones include:
- prednisone
- betamethasone
Posterior to the stomach and behind the parietal peritoneum, is divided into three anatomic areas.
pancreas
What are the three areas of the pancreas?
- the head (lies within the loop of the duodenum)
- the body
- the tail
The pancreas functions as a exocrine gland for _____ and as an endocrine gland for _____.
digestion
release of hormones
The primary source for the vital digestive enzymes amylase, lipase, and proteinase.
exocrine pancreas
Closely associated with blood vessels, which facilitate the transport of pancreatic hormones to the body.
endocrine portion of the pancreas
Pancreatic hormones are produced by clusters of cells called _____ or _____.
pancreatic islets or the islets of Langerhans
Pancreatic alpha cells secrete _____.
glucagon
Pancreatic beta cells secrete _____.
insulin
Regulates metabolism of glucose.
glucagon and insulin
Glucagon is a protein; it stimulates the liver to _____, thus increasing blood sugar levels.
break down glycogen into glucose
Insulin, also a protein, stimulates the liver to _____, thus lowering blood sugar levels.
form glycogen from glucose
Caused by an autoimmune disorder in which the body attacks its own pancreatic B-cells; body fails to produce insulin
Type-1 diabetes
The body’s tissues fail to respond to the action of insulin on target cells; may be effectively managed with diet and exercise or administration or oral antidiabetic drugs.
Type-2 diabetes
True or False: Medications used to treat diabetes are not administered from the sterile back table.
True
Located in the pelvic cavity, paired glands that produce estrogen and progesterone.
ovaries
Critical to the development and maintenance of female sex characteristics, including the menstrual cycle, pregnancy, and lactation.
estrogen and progesterone
Used as oral contraceptives (birth control hormones) and may be used for hormone replacement therapy (HRT) after menopause or oophorectomy.
estrogen and progesterone
May be used to treat symptomatic endometriosis of pregnancy is not desired and symptoms of fibrocystic breast changes
birth control hormones (estrogen and progesterone)
Used for palliative treatment of advanced androgen-dependent prostate cancer and metastatic breast cancer.
estrogen
May be used on vaginal packing placed after vaginal hysterectomy and administered from the back table.
Cream form of estrogen
True or False: Estrogen and progesterone are not routinely administered from the sterile back table.
True
Produce male sex hormones called androgens.
endocrine cells in the testes
Critical for the development of male sex organs and maintenance of secondary sex characteristics.
androgens, primarily testosterone
May be used to treat hypogonadism and some types of advanced breast cancer in females.
testosterone