Super Boards NAVLE comprehensive Study Guide Flashcards
Black widow spiders
Latrodectus mactans, L. hesperus
acetylcholine is the toxin binds calcium channels leading to ascending motor paralysis and destruction of peripheral nerves
p wil be recumbent, being in pain, vocalize, rigidity and muscle spasms and death
warfarin
An anticoagulant – interferes with II, VII, IX, and X
Give Vitamin K1, if chronic give plasma as well
Prothrombin time (PT) will be prolonged soonest after ingestion – because VII has shortest half life and is part of extrinsic system
Brodifacoum
D-con – inhibits epoxide reductase (loss of Vitamin K – interferes with II, VII, IX, and X)
Give Vitamin K, monitor prothrombin time (PT)
Cholecalciferol
gets converted to active Vitamin D to cause increased resorption of calcium and gut absorption of calcium leading to sometimes fatal HYPERcemia
Ethylene glycol
High anion gap, azotemia, calcium oxalate crystalluria, metabolic acidosis, hyperglycemia, and either polyuria or oliguria (anuria in worst case), hypocalcemia (from chelation of Ca by EG metabolites)
Treatment aimed at alcohol dehydrogenase – give 4- methylpyrazole (4-MP) – does not work in CATS
Organophosphate
Inhibit acetylcholinesterase causing muscarinic signs such as hypersalivation, incoordination, and bloat
Treatment = atropine or 2-PAM (pralidoxime – anticholinesterase)
.
.
Strychnine is snail bait
Competitively antagonizes action of glycine – loss of impulse contractility in the spinal cord and brainstem – affects striated muscle
Give methocarbamol (for convulsions), prevent stimulation
Acetominophen in cats
cats lack glutathione and glucoronyl transferase- leads to methmeogobinemia and tx with N-acetylcysteine
HEINZ BODY ANEMIA
methylene blue, molybdenum deficiency, rye grass, brassica family
Zinc and onions can cause hemolytic anemia
what lesion(s) do you see with salt toxicity
perivascular infiltration of eosinophils
cooper toxicity is common in ____ and ____ are resistant
sheep; pigs are resistant
sheep will get hemolytic anemia and will see methemoglobinemia
what does deficiency of copper look like in sheep? What about toxicity?
def- ataxia, swayback and ascending paralysis
copper toxicity in sheep will have hemolytic anemia and will see methemoglobinemia
Grapes and raisins cause renal failure in dogs, but in cats we mostly worry about ____
lilies (the stargazer lily from the lillium family is the worst)
what affects pigs by acting as a potent estrogenic metabolite produced by Fusarium causing hyperestrogenism and pseudopregnancy?
Zealalenone
salt poisoning causes what lesion specifically?
perivascular infiltration of eosinophils
copper toxicity vs deprivation in sheep
toxicity- hemolytic anemia and methemoglobinemia
deficiency- swayback, ataxia, progressive ascending paralysis
grass tetany aka staggers
Hypomagnesia can cause which is important for the nervous system function and enzyme reactions and occurs in lactating animals in early spring with lush pastures that are well fertilized
causes restlessness, staggers, over alertness, excitable, convulsions and maybe even death
Slaframine
moldy red clover, causes hypersalivation
oak leaves and acorns
hemorrhagic diarrhea, abdominal pain, tenesmus, colic, death
in cattle it causes renal damage but not the case for horses
Ergotism
Caviceps purpura aka a parasitic fungus (found in rye oats, wheat and KY bluegrass), alkaloids causes vascular constriction, thrombosis, colic, etc.
what are the toxic plants that are neurotoxins (there are 7 of them)
Blue green algae, night shade, water hemlock, perennial ryegrass, lead poisoning, sorghum, yellow start thistle
what neurotoxin causes a lesion that is myelomalacia of the lower SC?
Sorghum
yellow star thistle causes what lesion?
nicropallidal encephalomalacia where there will be loss of prehension (dystonia of the lips and tongue) and has grave prognosis