Super Boards NAVLE comprehensive Study Guide Flashcards
Black widow spiders
Latrodectus mactans, L. hesperus
acetylcholine is the toxin binds calcium channels leading to ascending motor paralysis and destruction of peripheral nerves
p wil be recumbent, being in pain, vocalize, rigidity and muscle spasms and death
warfarin
An anticoagulant – interferes with II, VII, IX, and X
Give Vitamin K1, if chronic give plasma as well
Prothrombin time (PT) will be prolonged soonest after ingestion – because VII has shortest half life and is part of extrinsic system
Brodifacoum
D-con – inhibits epoxide reductase (loss of Vitamin K – interferes with II, VII, IX, and X)
Give Vitamin K, monitor prothrombin time (PT)
Cholecalciferol
gets converted to active Vitamin D to cause increased resorption of calcium and gut absorption of calcium leading to sometimes fatal HYPERcemia
Ethylene glycol
High anion gap, azotemia, calcium oxalate crystalluria, metabolic acidosis, hyperglycemia, and either polyuria or oliguria (anuria in worst case), hypocalcemia (from chelation of Ca by EG metabolites)
Treatment aimed at alcohol dehydrogenase – give 4- methylpyrazole (4-MP) – does not work in CATS
Organophosphate
Inhibit acetylcholinesterase causing muscarinic signs such as hypersalivation, incoordination, and bloat
Treatment = atropine or 2-PAM (pralidoxime – anticholinesterase)
.
.
Strychnine is snail bait
Competitively antagonizes action of glycine – loss of impulse contractility in the spinal cord and brainstem – affects striated muscle
Give methocarbamol (for convulsions), prevent stimulation
Acetominophen in cats
cats lack glutathione and glucoronyl transferase- leads to methmeogobinemia and tx with N-acetylcysteine
HEINZ BODY ANEMIA
methylene blue, molybdenum deficiency, rye grass, brassica family
Zinc and onions can cause hemolytic anemia
what lesion(s) do you see with salt toxicity
perivascular infiltration of eosinophils
cooper toxicity is common in ____ and ____ are resistant
sheep; pigs are resistant
sheep will get hemolytic anemia and will see methemoglobinemia
what does deficiency of copper look like in sheep? What about toxicity?
def- ataxia, swayback and ascending paralysis
copper toxicity in sheep will have hemolytic anemia and will see methemoglobinemia
Grapes and raisins cause renal failure in dogs, but in cats we mostly worry about ____
lilies (the stargazer lily from the lillium family is the worst)
what affects pigs by acting as a potent estrogenic metabolite produced by Fusarium causing hyperestrogenism and pseudopregnancy?
Zealalenone
salt poisoning causes what lesion specifically?
perivascular infiltration of eosinophils
copper toxicity vs deprivation in sheep
toxicity- hemolytic anemia and methemoglobinemia
deficiency- swayback, ataxia, progressive ascending paralysis
grass tetany aka staggers
Hypomagnesia can cause which is important for the nervous system function and enzyme reactions and occurs in lactating animals in early spring with lush pastures that are well fertilized
causes restlessness, staggers, over alertness, excitable, convulsions and maybe even death
Slaframine
moldy red clover, causes hypersalivation
oak leaves and acorns
hemorrhagic diarrhea, abdominal pain, tenesmus, colic, death
in cattle it causes renal damage but not the case for horses
Ergotism
Caviceps purpura aka a parasitic fungus (found in rye oats, wheat and KY bluegrass), alkaloids causes vascular constriction, thrombosis, colic, etc.
what are the toxic plants that are neurotoxins (there are 7 of them)
Blue green algae, night shade, water hemlock, perennial ryegrass, lead poisoning, sorghum, yellow start thistle
what neurotoxin causes a lesion that is myelomalacia of the lower SC?
Sorghum
yellow star thistle causes what lesion?
nicropallidal encephalomalacia where there will be loss of prehension (dystonia of the lips and tongue) and has grave prognosis
what are the (5) reproductive toxins?
False helbore
Locoweed
Fescue
Lupine
Pondersoa Pine Needles
what does bracken fern do as a toxin?
bone marrow suppression and thiaminase
Can cause polioencephalomalacia due to thiaminase – more so in HORSES than other animals
what toxin is a vitamin K antagonist that causes hemorrhage but NOT hemolysis and PT time will be prolonged
Moldy sweet clover
all ____ are toxic to HORSES
ionophores
what are the 3 pulmonary toxins?
Perilla mint
Moldy sweet potatoes (produces 4-ipomeanol)
Brassica plants which are cabbage, kale, etc. (Causes FOG fever via 3-methyl-indole)
what are the (2) hepatic toxins?
pyyrolizidine alkaloids (like fiddleneck, ragwort, st johns wort, senecio) and alflatoxins (mycotoxin)
what is the difference between primary and secondary photosensitization?
*Primary photosensitization =
Contain hypericin which causes large areas of skin sloughing, mainly unpigmented areas
*Secondary photosensitization due to liver disease – usually chlorophyll in diet is converted to phylloerythrin and excreted by the liver – with hepatic disease it is deposited in skin – UV reacts with it and causes dermal damage
aflatoxin is a _____
mycotoxin
how can we cross match blood types?
Major= donor’s RBCs vs. recipient plasma
Minor= donor plasma vs. recipient RBCs
to raise PCV 1%, how much do we need to raise packed RBCs in ml/kg
to raise PCV 1% we need to give 1mL/kg of packed RBCs
what does suppurative mean? Granulomatous? Pyogranulomatous?
Suppurative means full of neutrophils
Granulomatous means mononuclear cells (lymphocytes, macrophages, plasma cells)
pyogranulomatous means mixed neutrophils and mononuclear cells (lymphocytes, macrophages, and plasma cells)
Von willebrands
Dobies, def of factor VIII (Hemophilia A) or IX (Hemophilia B) related antigen, so platelet function abn due to inability to adhere subendothelial collagen, tx with cryoprecipitate or Desmopressin which is an ADH inhibitor and clotting drug
canine thrombopathia
inherited where platelets fail to aggregate and secrete their granules, coagulation and platelet numbers are normal, seen in Basset Hounds
Microcytic (smaller) hypochromic (less red) non-regenerative anemia means
iron deficiency
what cytokine is most impt in systemic inflammation response syndrome aka SIRS???
Interleukin 1 (IL-1)
hypersensitivities
Type 1- IgE mediated, immune mediated (like vax rxn)
Type 2- Antibody dependent reactions, occurs due to IgG or IgM made against normal self antigens
Type 3- immune complex mediated (like sulfa drugs in doberman pinchers)
Type 4- delayed hypersensitivity cell mediated
ECF to ICF ratio is
1:2
ECF to ICF
1/3 ECF 2/3 ICF
Heart sounds S1-S4
Lub dub sounds
S1 = closure of the AV valves
S2 = closure of pulmonic and aortic valves-diastole
S3 = very subtle ventricular relaxation
S4 = very subtle, atrial contraction
The first “lub-dub” is the sound of the mitral and tricuspid valves closing. The second “lub-dub” is the sound of the aortic and pulmonary valves closing soon after.
failure of closure of the foramen ovale causing shunting from ____ ____ to ____ ____
from left atrium to right atrium
what is the most common congenital heart defect in cattle, horses, and cats???
Ventricular septal defect (VSD)
Dextropositioned aorta (overriding aorta), pulmonic valve stenosis, ventricular septal defect, right ventricular hypertrophy is what condition?
Tetralogy of fallot
Everything that went wrong with Tetralogy of Fallot? What does it cause?
Overriding aorta, pulmonic valve stenosis, ventricular septal defect, right ventricular hypertrophy causing right sided heart failure and a right to left shunt
PDS are usually what side to what side?
usually left to right
what will we hear with PDA? What will we see on rads?
Continuous washing machine murmur (hear on both sides of chest) with waterhammer pulses
Radiographs = enlarged left heart with bulge of aorta near PDA on DV if left to right shunt which most of them are–> Only see right ventricular enlargement with PDAs that are shunting right to left which is not common
What is the most common congenital heart defect in dogs and how is it treated?
PDA and is treated with surgical ligation of the PDA, coil embolization BUT ONLY FOR LEFT TO RIGHT SHUNTS (which are the most common ones)
what heart valve in the cow is most commonly affected by valvular endocarditis?
tricuspid valve (and mitral)
what heart valve in the small animal and horse is most commonly affected by valvular endocarditis
aortic valve (also mitral)
diagnosis of valvular endocarditis is….
vegetative lesions of heart valves, positive blood culture
why do we not give furosemide to pericardial effusion cases?
causes decreased preload on the right heart causing circulatory failure
ECG with hyperkalemia
no p wave, tall tended T waves, increased P-R interval and widened QRS complexes
what causes right heart failure in cattle?
traumatic reticulopericarditis
Aspiration pneumonia characteristics on rads and on auscultation
Harsh lung sounds and crackles heard cranioventrally
Radiographs show alveolar pattern in right cranial and middle lung lobes
UMN signs
hyperreflexes, increased muscle tone
LMN signs
decreased or absent spinal reflexes and decreased muscle tone
Localizing lesions
C1-C5- all 4 limbs show signs of UMN
C6-T2- LMN signs to thoracic limbs, UMN signs to pelvic limbs
T3-L3- UMN signs in pelvic limbs, normal thoracic limbs
L4-S4 -LMN signs in pelvic limb (and anus and bladder), normal thoracic limbs, dropping feces and urine and will not have anal reflex
assess cranial nerve 2 (optic nerve) with what?
papillary light reflex and dazzle reflex
assess cranial nerve 3 (oculomotor nerve) with what?
strabismus of the eye
what does it mean if an animal has medial strabismus?
other eye notes in description answer
Loss of CN VI (Abducens nerve)
Eye movements are controlled by the oculomotor (III), trochlear (IV) and abducens nerves (VI).
With loss of CN III (oculomotor nerve) a ventrolateral strabismus occurs
CN IV (trochlear nerve) loss results in an outward rotation of the top of the eye. In an animal with a round pupil like the dog, this can be detected by the position of the vessels in the fundus.
Loss of CN VI (abducens nerve) function results in medial strabismus and absent globe retraction.
a CN lesion where causes dysphonia, dysphagia, abnormal vocalizing, inspiratory dyspnea, megaesophagus
CN 10 which is the vagus nerve
what are all of the characteristics of horners syndrome?
3rd eyelid protrusion, enophthalmos (retracted globe), ptosis (dropping eyelid), miosis (constricted pupil); in large animals may also see sweating
MONONUCLEAR PLEOCYTOSIS on CSF tap, microabscesses in brainstem and cranial nerve roots is what disease?
Listeria (tx with penicillin- it is zoonotic so beware)
IN CATTLE- NEUTROPHILIC PLEOCYTOSIS on CSF tap, xanthochromic/cloudy due to increased neutrophils is what disease?
Thromboembolic Meningoencephalitis (TEME) = Histophilus somnus
what does it mean when you find xanthochromic CSF fluid?
evidence of prior hemorrhage (yellow discoloration)
what do we do in a patient in active epilepticus?
Give diazepam rectally
what is the tx goal in patients with head trauma and why?
minimize intracranial pressure by keeping a HIGH PaO2 to keep cerebral bf low without causing any hypoxia
what is the cushings reflex?
bradycardia and hypertension
how does the inner ear connect with the pharynx and such?
eustachian tube
what form of shock is ALWAYS associated with primary heart disease?
Cardiogenic shock
what are some causes of metabolic acidosis in cattle? What about alkalosis in horses?
Cattle- acidosis from salivation or dehydration
Horse- alkalosis- loss of chloride in saliva and sweating in horses
low ___ is called hypoxia
low PO2 is called hypoxia
Lyme disease is caused by ___ tick from what animal most commonly?
Ixodes tick; usually from white-footed mouse
Canine granulocytic ehrlichia is caused by what tick?
(E. wingii) caused by Amblyomma aka lone star tick
canine monocytic ehrlichiosis
(Ehrlichia canis) caused by Rhipicephalus (brown dog tick)
What tick is responsible for causing rocky mountain spotted fever (causing bacteria Rickettsia rickettsii)?
Dermacenter (American dog tick)
CS of rock mtn spotted fever is the same as Ehrlichia, how can you differentiate them?
rocky mtn spotted fever CS is over in 2 weeks and causes more vasculitis (tx the same thooo= Doxycycline)
Tularemia
zoonotic, rabbits carry it with the tick being the vector, can be used for biological warfare and cats affected more than dogs
Cytauxzoon felis
cat disease caused by the Dermacenter tick and is almost 100% fatal, causes ring shaped orgs in RBCs or schizonts in the spleen, liver, blood, BM, or LN and causes anemia with poor prognosis
needs heparin blood transfusion and azithromycin for Tx
Anaplasma marginale in cattle
TICK – but any blood feeding insect can transmit, so can needles/veterinary instruments
!!!EXTRAVASCULAR HEMOLYSIS – NO HEMOGLOBINURIA (how you differentiate from leptospirosis, bacillary hemoglobinuria, and anthrax)!!!!
Tx is oxytetracycline
Babesia is a malaria like parasite causing RBC destruction and what two breeds are predisposed? What is the vector? What is the tx?
Greyhound and pitbulls predisposed; Boophilus ticks are vectors
TX is imidocarb
Epizootic bovine abortion aka foothill abortions in california foothills vector and CS
vector is Ornithodoros coriaceus (soft tick) and the CS is aborted fetuses with enlarged LN, spleen, and destructive lesions to the thymus
what are the ticks that like to irritate cattle ears?
Otobius megnini
what does Histoplasma look like under microscope what is the CS?
small intracellular cysts and causes large bowel diarrhea
Cryptococcosis CS, where is it found and what does it look like under the microscope? How is it tx?
resp and ocular disease with roman nose, lymphadenopathy; survives in pigeon droppings, will see small yeast with large capsule and narrow based budding; tx is Fluconazole
Aspergillosis on histopath looks like this…. what is the Tx?
Branching fungal hyphae on HISTOPATHOLOGY (not cytology!!!), can also see fungal plaques and tx with Clotrimazole (post recovery may see severe laryngeal edema)
Coccidiomycosis- what will you see on microscope? What are CS?
Will see spherule with is double walled containing endospores; CS similar to blasto but you will ONLY SEE SOME SKIN LESIONS IN CATS
ketoconazole causes ____ in cats
vomiting
What causes cutaneous larval migrans in people?
Hookworm (Ancylostoma caninum)
what causes visceral and ocular larval migrans in humans?
Round worms (Toxocara canis/cati)
tx of tapeworms is______ tx of whipworms is _____
tapeworms is praziquantel; tx of whipworms is fenbendazole
a kitten with unresponsive diarrhea likely has what flagellated parasite? How do you tx it?
Tritrichomonas foetus; tx with Ronidazole
what parasite causes sheep, pig, dog, and cat abortions or stillbirth sometimes? What is the tx?
Toxoplasma gondii; tx with Clindamycin
what causes larval migrans to the brain causing CNS disease in humans?
Racoon roundworm aka Baylisascaris procyonis
leishmania is transmitted by …
sand flies
Types I ostertagia ostertagii (cattle roundworm)
acute weight loss and diarrhea in naive cows, occurs in winter and spring, egg counts high
Type II ostertagia ostertagii (cattle roundworms)
chronic weight loss and diarrhea, in older cows, occurs in fall and winter and LOW egg counts with thousands of larvae in the abomasum “Moroccan leather”
ostertagia osteragii tx
ivermectin or fenbendazole
what are some marked differences between Ostertagia ostertagii 1 and 2 in cattle (which are the roundworms of cattle)??
Type 1 has low egg counts and occurs in winter AND spring and not assoc. with abomasum
Type 2 is in the fall and winter, LOW egg counts, THOUSANDS i the abomasum and causes “Moroccan leather” appearance of the abomasum
what parasite has rectangular look under microscope and is found in cattle?
Monezia aka cattle tapeworm
what is the scientific name for threadworm in cattle?
Strongyloides
what parasite in horses causes resp. signs bc migrates through the lungs and can cause intestinal impaction colic in YOUNG foals and can cause hypersensitivity in adults??
Parascaris equorum aka roundworm (ascarid)
what parasite causes diarrhea in foals and they get it from their dam’s milk?
Strongyloides westeri (can give preg mare ivermectin to prevent this)
horses near cattle are at increased risk for this parasites?
Trichostrongylus axei aka small stomach worm aka hairworm and Haematobia irritans (horn/face fly) which causes crusting on ventral midline that is NOT itchy and will have wheels
what is the stomach bot where you see little yellow fly bot eggs?
Gasterophilus intestinalis
where does Hypoderma bovis migate? Where does hypoderma lineatum migrate?
Hypoderma bovis migates to the epidural fat in the SC; Hypoderma lineatum migrates to the esophagus
(tx with ivermectin in fall)
Onchocerca cervicalis
dermatitis due to hypersensitivity of dying microfilaria, aberrant migration causes some eye changes, diamond shaped lesions, and ventral midline dermatitis
vector is culicoides and is tx with ivermectin for microfilaria but there is no tx for the adults
what is sweet itch?
Culicoides (type 1)hypersensitivity, seasonal in warmer months, tx by decreased exposure and steroids
Horse with ventral dermatitis that is non itchy can be what parasitic causes?
Onchocerca cervicalis and Haematobia irritans
what causes summer sores in horses?
Habronema muscae aka stomach worm from stomoxys calcitrans (housefly) vector (the lesions will have calcified centers of larvae and causes gastritis, eosinophilic granulomas which are the famous “summer sore”)
What is the vector for Habronema muscae aka stomach worm
stomoxys calcitrans (housefly)
scabies is most economically important in what species?
swine (causes hyperkeratotic ear lesions mostly and they will be soooo pruritic)
scabies tx
ivermectin
Chorioptes equi aka equine mange mites lesions and tx
near the foot/fetlock, causes pruritic dermatitis
tx with ivermectin
Thelazia lacrymalis
Caused by musca autumnalis aka face fly of horses as the vector
how to treat Thelazia lacrymalis aka eyeworm from Musca autumnalis (face fly) in horses?
manual removal and then 10% Levamisole drops
A sheep with sneezing and head shaking presents to you. The sheep is not up to date on anything as they just purchased it from a local farm. What is a parasitic ddx? How is it treated?
Oestrus ovis which is where fly deposits larvae in the nostils and they migrate up the nose
cytology shows eosinophils and mast cells
Tx is Ivermectin
what are the blood-sucking louse in cattle? How is it diagnosed?
Hematopinus species; causes in anemia in calves and can cause pneumonia; diagnosis with skin scrape seeing lice which have 6 legs
what is the vector causing Trypanosomiasis which causes “Nagana” in cattle and sleeping sickness in humans
Tsetse fly
What is the vector of Chaga disease?
Reduvid beetle causes Chaga’s disease which is has the parasite Trypanosoma cruzi
Chaga disease from parasite ____ _____
Trypanosoma cruzi
what parasite in rigs causes the following:
Migrates thru liver and causes milk spots and migrates thru the lungs and causes thumps and can cause death from intestinal impaction?
Ascaris suum (roundworm)
what is the tx for ascaris suum (roundworms) in swine?
fenbendazole
what parasite causes MUCOHEMORRHAGIC DIARRHEA in swine in all ages and seen by double operculated egg aka football shape
Trichuris suis (whipworm)
what is the pork tapeworm? What does it cause in humans?
Taenia solium; zoonotic and causes cysticercosis
(this is gross but pigs are the IH and eat infected human feces so then cysticerci are in the pig’s muscle and humans eat that pig meat undercooked and get it)
what parasite causes high mortality in pigs under 3 weeks old and looks like E. coli but WILL NOT respond to any Abx???
Isospora suis aka coccidiosis (needs to be tx with Amprolium)
what is a worm that pigs get from colostrum in sows that are not UTD on dewormings?
Strongyloides randomi (threadworm)
A swine eating earthworms is at risk for what parasites (2)?
Metastrongylus aka lungworm and Stephanarus dentatus which is the kidney worm
what are the two parasites that humans can get from eating undercooked pork?
Taenia solium (tapeworm) and Trichinella spiralis
how do pigs get trichinella spirals and how do humans get it?
Pigs get it from eating garbage/meat of other infected animals and humans get it from eating encysted larvae from undercooked pork meat
Doxorubicin is ____ in dogs and _____ in cats
cardiotoxic in dogs and renaltoxic in cats
what chemo drug can cause sterile hemorrhagic cystitis
cyclophosphamide (super hydrate the animal before giving)
what chemo drug can cause paralytic ileus
vincristine
what chemo agent can cause anaphylaxis? What about fatal pulmonary edema in cats?
L-asparaginase; Cisplatin
what chemo drug cannot be used in cats?
Cisplatin (will cause fatal pulmonary edema– “Cisplatin makes cats go spat”)
what chemo drug is neurotoxic in cats?
5-Fluorouracil
enucleate a cow eye with lymphoma is TOC T/F
False, euthanize and meat cannot be used
goats and sheep get this neoplasia in their nasal passages due to a virus
nasal adenocarcinoma
Carcinoma is tumor of what cells? What do you see on cytology?
epithelial cells; see cohesive clusters of cells with tight junctions
Sarcoma is a tumor of what cells? What do you see on cytology?
mesenchymal cells; will see spindle shaped cells with elongated cytoplasm
Round cell tumor examples
Lymphomas, mast cell (will see granules), plasma cell, histiocytic cell tumors, TVT (will have vacuoles)
a rise in ____ means a fall in GFR
creatinine
___% or more of renal function must be loss for a dog to be azotemic
75%
What stimulates the release of Anti-diuretic hormone?
Release is stimulated by = hyperosmolality and decreased circulating blood volume
It increases renal water resorption and urine osmolality by increasing permeability of collecting tubules
Osmoreceptors in the hypothalamus detect changes in plasma osmolality and release ADH accordingly
Umbilical arteries become what? What do umbilical vein become? What about urachus?
Umbilical a= round ligament of bladder (caudal)
Urachus becomes middle ligament of bladder
Umbilical v= falciform ligament (cranial)
what nerve provides sympathetic innervation to the bladder? What about parasympathetic?
Sympathetic is hypogastric nerve and parasympathetic is pelvic nerve
what nerve provides somatic innervation to the bladder?
pudendal nerve
what has to occur for bladder emptying?
parasympathetic stimulation and sympathetic inhibition where pelvic n. stimulates detrusor muscle that results in contraction of the bladder to express urine
STORAGEEEE of urine involves what two nerves being activated?
Sympathetic and somatic nerves being activated
why does renal failure cause metabolic acidosis?
low bicarb bc kidneys are injured
renal failure tx
SQ fluids and renal diet, H2 receptor antagonist, oral phosphate binding agents, restrict dietary proteins, calcium channel blocking agents
what are some sequelae conditions from renal failure?
loss of ability to make calcitriol (active form of vitamin D), chronic weight loss, gastric ulcers, secondary hyperparathyroidism)
what are the 4 main components for nephrotic syndrome (which occurs with PLN)?
Proteinuria, hypercholesterolemia, edema/ascites, hypoproteinemia
Urolithiasis in equine is made up of ___ _____ and form in acidic or alkaline urine
calcium phosphate; alkaline urine
what is the most common stone in sheep eating off a lush pasture (and is the most common urolith in equids also)
calcium carbonate
What stones are common in cattle and sheep grazing on western rangeland?
silica stones
struvite is made of what 3 components? what type of pH does it form in?
calcium, magnesium, and phosphate and forms in alkaline urine (seen in animals getting a lot of grain or in dogs/cats in conjunction with UTI)
Calcium oxalate forms in what pH of urine?
acidic urine
can you see cystine or urate on rads?
nope
urate stones
common in PSS patients and Dalmatians (defect in urate metabolism) and tx with allopurinol
what form of dermatophytosis aka ringworm do cattle and goats get?
Trichophyton verrucosum mostly
what are the most common serovars of Leptospirosis in dogs (3)?
Grippotyphosa, Bratislava, Pomona
what do progesterone and estrogen do during proestrus? What about estrus? diestrus?
Proestrus- Progesterone drops and estrogen rises
Estrus- progesterone lowers, estrogen is high (cornified epithelium and LH surge)
Diestrus- progesterone is high (this is where pyometras occur)
pig gestation is ____ days and pregnancy depends on ____ sources of progesterone
114 days; depends on ovarian sources of progesterone throughout all of gestation
sheep and goat gestation is ____ days and sheep estrous is ____ days whereas goat estrous is ____ days
gestation is 150 days; sheep estrus is 16 (14-19 days) days; goat estrus is 21 days
cattle estrous length is ___ days with a ___ day estrus cycle
21 days; they are in estrus for 8-20 hours
when do cattle ovulate?
about 24 hours after onset of estrus (do intrauterine insemination around this time)
In what ways can you synchronize estrus in cattle?
give 2 injections of PGF-2 alpha (prostaglandins) 11-14 days apart to lyse CL and will see estrus in 3 days
when can you use dexamethasone and PGF2 alpha to abort a cow’s fetus?
After 4 months of gestation—but if you want to be able to use just PGF2 alpha then you can do it after 8 months
when can you provide light to mares so she will start cycling again? How long is a horse in estrus?
provide artificial light for 16 hours per day 60 days prior to the start of breeding; a horse has estrus for 2-10 days (average is 6 days)
takes ___ days for spermatogonia to mature to sperm
60 days (2 months)
dog and cat gestation is ___ days
63 days
a rise in prolactin and fall in progesterone can cause _____
pseudopregnancy (will have mammary development, lactation, nesting, mothering of toys, etc.)
T/F 70-90% of mammary gland tumors in cats are considered malignant and majority of them will metastasize
True!!!
Stats on dogs spayed and chance of mammary gland tumors
dogs spayed prior to estrus are 0.05% times as likely to develop mammary tumors as an intact dog, risk rises to 8% and 26% after one or two heats respectively with no decrease in risk if they are spayed after the third heat
mammary tumors in cats vs dogs
in cats 70-90% are malignant and tx is radical sx of the chain but in dogs, only 50% are malignant
use the spay hook to get what specific structure (according to NAVLE)
Broad lig of uterus
what will you see on cytology of a cat you think has ovarian remanent syndrome??
mostly cornified epithelial cells (also will have low LH)
pyometra occur when? during the influence of what hormone? what are the 2 main causes/predilections to pyometra???
occur in diestrus under the influence of progesterone
common causes are E. coli; or if dog is over 8 years old, may be cystic endometrial hyperplasia (which develops from repeated exposure to progesterone)
Salter Harris fractures 1-5 (remember, salter harris only applies to physeal fractures (physis is the GROWTH PLATE)
Type 1 = physis
Type 2 = physis and metaphysis
Type 3 = physis and epiphysis
Type 4 = metaphysis, epiphysis, physis
Type 5 = compression/crush injury to physis
what do we want for articular fx fixations?
rigid fixation, anatomic realignment, early return to function
HO vs HOD
HO is due to thoracic mass with limbs also affected
HOD is in young and large growing breeds and may be contributed to Ca/Phosphorus imbalance and is SUPER PAINFUL and affects the metaphysis “double physis line” but usually resolves on its own
what are the layers of the tear film?
Mucous portion – goblet cells
Aqueous portion – lacrimal gland, gland of third eyelid
Lipid portion – meibomian glands
What is the most common cause of cataracts in cats?
anterior uveitis
what is the tx of cataracts (which is increased opacity of the lens)
phacoemulsification
tx of glaucoma
IV mannitol (decrease IOP through osmosis), oral or topical methazolamide/dorzolamide (carbonic anhydrase inhibitor – decreases aqueous production), topical latanoprost (prostaglandin analog)
Prognosis of glaucoma
if they have glaucoma in one eye, will develop in other eye within 6-12 months
what are the signs of anterior uveitis?
Rubiosis iridis (small fine blood vessels everywhere- neovascularization aka making new bf everywhere), aq. flare, hyphema (blood in the anterior chamber), decreased IOP
what are the sequelae of anterior uveitis?
cataracts, glaucoma, corneal scarring
T/F KCS is a common sequelae of anterior uveitis
False, ant. uveitis cannot extend that far into the lacrimal gland and cause KCS
what is this disease:
gray spots throughout the fundus, retinal hemorrhage, hyperreflectivity
Chorioretinitis
Anisocoria definition
one pupil dilated and one constricted (sign of severe head trauma)
Lens luxation is common in what breeds? what type of luxation would require immediate lens removal?
common in TERRIERS; anterior luxation needs immediate lens removal
what is the normal aging change to center of the lens?
nuclear sclerosis
what is the tx for KCS??
cyclosporine eye drops (revereses immune mediated process, stimulates tear production, topical steroids (reduces immune destruction of lacrimal gland)
what drugs can cause KCS?
TMS, atropine, anesthesia, etodolac aka strong NSAID I ain’t never heard of
immune mediated adenitis is the main cause of what eye condition?
KCS
what is normal STT
15mm/60 seconds
Uncomplicated eye ulcers will heal in less than ___ days (present less than 1 week means uncomplicated)
5 days
what is the tx of complicated eye ulcers
conjunctival flap
what is the tx for melting corneal ulcer?
swab for cytology and culture (always assume its infected)
Uveal cyst vs. uveal melanoma
Cyst = brown, round circular FREE FLOATING mass in anterior chamber – will TRANSILLUMINATE
Melanoma = brown, round circular NON-free floating mass – will NOT transilluminate and usually has more irregular boarders
what abx cause cartilage abn in young animals?
enrofloxacin
do not use what abx in rodents?
Streptomycin (anything ending in -ycin because causes clostridial enterotoxaemia
what abx do we like to use in rodents?
enrofloxacin, chloramphenicol and TMS
most foodborne illnesses in the US is caused by bacteria T/F
False, 2/3 of it is caused by viruses in the US
what, in humans, is a syndrome lead on by resp. or GI infections (like food poisoning)
Guillian- Barre Syndrome
____ produces shiga-like toxins?
E. coli
cattle have no symptoms for E. coli so how do we test for it/check for carriers in the herd? What media is it grown on?
ID carrier by sending a stool sample out for 0157:H7 fecal culture from random sampling of the herd and it will be grown on sorbitol MacConkey agar bc it ferments sorbitol
raw honey sometimes has what zoonotic pathogen
botulism (do not feed to babies)
psychrophilic means
grows at low temperatures
What does listeria cause in humans?
abortions and stillbirths