Summary of Intended Learning Outcomes Flashcards
Describe the main features of the fluid mosaic model of biological membrane structure and discuss the features of membrane asymmetry and cytoskeletal interactions
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Describe how membrane transporter mechanisms and ion channels contribute to the maintenance of ionic gradients across membranes, the transport of solutes through membranes and the regulation of intracellular pH and cell volume
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Describe the ionic basis of the membrane potential
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Describe the properties of voltage-gated ion channels, the general features of electrical excitability of membranes, and the permability changes associated with the action potential
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Discuss factors affecting impulse conduction velocity in nerves
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Describe and compare biological communication processes involving hormones, local mediators and neurotransmitters
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Outline the variety of receptor mechanisms which influence the behaviour of cells
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Outline the variety of effector mechanisms involved in cellular signalling pathways, including the concepts of transducing proteins, second messengers and signal pathway cascades
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Define the concept of receptor specificity, and define the terms agonist and antagonist. Distinguish competitive and non-competitive antagonism
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Describe the anatomical and pharmacological divisions of the autonomic nervous system. Outline the steps of neurotransmission at cholinergic and adrenergic synapses in the autonomic nervous system and the mammalian neuromuscular junction
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Summaries whole-body considerations of drugs reaching their sites of therapeutic action, including priciples of drug bioavailability, inactivation and elimination and describe the adaptive changes which can occur in receptor populations when exposed to agonists and antagonists
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Describe the principles of drug action using the autonomic nervous system as an example drug target
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