4 - Electrical Excitability Flashcards
Describe the properties of voltage-gated ion channels, the general features of electrical excitability of membranes, and permeability changes associated with the action potential
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Discuss factors affecting conduction velocity in nerves
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Describe the properties of the action potential, its ionic basis and the associated changes in membrane ionic permeability
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Describe the basis of the all-or-nothing law and refactoriness in terms of these changes in permeability
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Describe the key molecular properties of ion channels
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Outline the action of local anaesthetics
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Illustrate the change in membrane potential that occurs during an action potential
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Describe how the ionic movements underlying the action protential occur
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Outline the properties of voltage-activated ion channels
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Explain the basis of refractoriness in nerve and muscle
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Explain how local anaesthetics work
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Describe the results of extracellular recording and how this can be used to measure conduction velocity
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Explain how axons are raised to threshold
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Explain the local circuit theory of propagation
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Explain how conduction velocity is linked to fibre diameter
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