5 - Effects of Electrical Signals - Ligand-Gated Ion Channels Flashcards
Explain the concept of ligand-gated channels, and describe the steps of neurotransmission at the mammalian neuromuscular junction
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Discuss the importance of the control of intracellular Ca++ concentration
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Outline how action potentias open Ca++ channels in cell membranes
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Describe some aspects of the diversity of Ca++ channels
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Describe events underlying fast synaptic transmission
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Describe some properties of ligand gated ion channels with nicotinic acetylcholine receptors as an example
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Describe the action of two types of blockers of nicotinic receptors
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Discuss the mechanisms contributing to the control of intracellular Ca++ concentration and their importance in cellular physiology
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Describe the general properties of receptor proteins
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Describe the different mechanisms receptors employ to transduce an extracellular chemical signal into an intracellular event
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Compare the proposed transport mechanisms of the plasma membrane Na+/K+-ATPase, the plasma membrane and sarcoplasmic reticulum Ca++-ATPases, and the Na+/Ca++-exchanger in regulating ion concentrations inside cells
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Describe the various receptor-effector mechanisms; receptor linked to ion channels, to G-proteins or to protein kinases. Understand the concepts of second messengers and cascades. Discuss the importance of cylic nucleotides and the control of intracellular Ca++ concentration
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Explain the concept of ligand-gated channels, and describe the steps of neurotransmission at the mammalian neuromuscular junction
w
Discuss the importance of the control of intracellular Ca++ concentration
w
