Sulphonylureas (SUs) Flashcards
1
Q
Mechanism
A
Bind to SUR1 on Katp channels causing depolarisation
Increase insulin secretion
2
Q
Glucose dependant or independent
A
Glucose independent
3
Q
Clinical use
A
Decreases blood glucose
4
Q
Name some drugs
A
Glicazide
End with -zide
5
Q
Side effects
A
Increase weight, risk of hypoglycaemia
No CV benefit
6
Q
When not to use
A
If liver/kidney disease
