GLP-1 receptor antagonists

Question 1

Mechanism

Answer 1

Activate GLP-1 receptors and inhibit breakdown of DPP4
Increase insulin secretion

Question 2

Glucose dependant or independent

Answer 2

Glucose dependant

Question 3

Clinical use

Answer 3

Decrease glucose
Decrease weight
Decrease BP
CV benefit

Question 4

Name some drugs

Answer 4

Liraglutide, semaglutide etc
Name ends -Glutide

Question 5

Side effects

Answer 5

Nausea and vomiting, Increase risk of gallstones, Bloating

Question 6

When not to use

Answer 6

If patient at risk of pancreatitis