SGLT2 inhibitors Flashcards
1
Q
Mechanism
A
Inhibits renal sodium glucose transporter 2
Increase urinary glucose excretion
2
Q
Glucose dependant or independent
A
Glucose independent
3
Q
Clinical use
A
Decreases blood glucose - decreases insulin and increases glucagon
CV benefit
4
Q
Name some drugs
A
Empagliflozin etc
End -flozin
5
Q
Side effects
A
Thrush, gangrene, hypovolaemia, hypotension, DKA
6
Q
When not to use
A
If they have renal problems, prolonged fasting or acute illness
