Metformin Flashcards
1
Q
Mechanism
A
Increases body’s sensitivity to insulin by increasing glucose uptake into cells
Inhibits complex 1 of mitochondrial resp chain
Decreases hepatic glucose production
2
Q
Clinical use
A
Decreases blood glucose and weight
CV benefit
3
Q
Glucose dependant or independent
A
Glucose dependant
4
Q
Side effects
A
Lactic acidosis, GI upset, diarrhoea, dyspepsia
5
Q
When not to use
A
If they have poor renal function
