Sulphonylurea Flashcards
1
Q
MoA
A
Lowers blood glucose by stimulating pancreatic insulin secretion.
2
Q
Short acting
A
Lower risk of hypo
Use in elderly + renal impairment
- Gliclazide
- Tolbutamide
3
Q
Long acting
A
Glibenclamide
Glimepiride
4
Q
Pregnancy
A
Glibenclamide in 2nd + 3rd trimester
5
Q
Side effects
A
- Hyponatraemia (glipizide, glimperide)
- Sulphonylurea-induced hypoglycaemia
- Weight gain
- Jaundice
- Hypersensitivity reactions in first 6-8 weeks e.g. skin rashes
6
Q
Sulphonylurea-induced hypoglycaemia
A
Treat in hospital - can persist for hours
Counsel patients to recognise HYPO symptoms, especially when driving.
Always carry sugary snack
Never miss meals
7
Q
Interactions
A
Other oral antidiabetics
Alcohol
Warfarin + ACEi = hypo
NSAIDs = reduced renal excretion
