Pioglitazone Flashcards
1
Q
MoA
A
Reduces peripheral resistance
2
Q
NICE recommendation
A
Continue if HbA1C reduced by 0.5% within 6 months
3
Q
Side effects
A
Heart failure
Bladder cancer
Hepatotoxicity
4
Q
Heart failure
A
Increased risk when combined with insulin
C/I in history of HF
5
Q
Bladder cancer
A
C/I in history of bladder cancer or un-investigated macroscopic haematuria
Caution in elderly (increased risk)
Counsel patient to report:
- Haematuria
- Dysuria
- Urgency
6
Q
Hepatotoxicity
A
STOP if jaundice occurs
Counsel pt to report:
- N + V
- Abdominal pain
- Fatigue
- Dark urine
- Itching
7
Q
Common SE
A
Bone fracture
Infection
Numbness
Visual impairment
Weight increase
8
Q
Caution
A
Elderly
Bone fractures esp women
Risk factors for HF/bladder cancer
