Sulfonamidas Flashcards

1
Q

Sulfonamidas

Mecanismo

A

Inhibidores competitivos de dihidropteroato sintasa
Análogos de PABA

Si pueden usar ácido folico preformado no son sensibles

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2
Q

Sulfonamidas

Resistencia

A

Menor afinidad de dihidropteroato
Permeabilidad

Causa necrois

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3
Q

Sulfonamidas

Efectos adversos

A
Cristaluria 
Anemia
Agranulocitosis 
Hipersensibilidad 
Necrosis hepatica
Kernicterus

Potencian efectos

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4
Q

Sulfametoxazol

+trimetoprim

A

Trimetoprim es una diamimopiridina que inhibe la dihidrofolato reductasa, +potente

Proporción 5:1

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5
Q

TMP SMX

Uso

A

IVU, Infecciones respiratorias, digestivas agudas

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6
Q

TMP SMX

Efectos adversos

A

75% en piel

Inhibe metabolismo de fenitoina y aumenta ciclosporina

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