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Pharmacology Exam 4 > Sufonamides, Trimethoprim, Quinolones > Flashcards

Sufonamides, Trimethoprim, Quinolones Flashcards

1
Q

What are anti-folate drugs? (2)

A

Sulfonamides

Trimethoprim

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2
Q

What inhibits the synthesis of dihydrofolic acid?

A

Sulfonamides

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3
Q

What inhibits the synthesis of tetrahydrofolate?

A

Trimethoprim

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4
Q

Dihydrofolate is inhibitor of what?

A

Dihydrofolic acid

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5
Q

Sulfonamides are:

bacteriostatic at _____ doses

bacteriocidal at _____ doses

______ is influenced by PABA analogs

A

lower (systemic)

higher (urinary)

Efficacy

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6
Q

What class is DOC for:

Prophylaxis of burn infections
Inflammatory disorders of the GI tract

A

sulfonamides

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7
Q

What class is 2nd line DOC for:

respiratory infections
uncomplicated UTI

A

sulfonamides

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8
Q

What are the sulfonamides? (2)

A

Sulfisoxazole

Sulfasalazine

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9
Q

What sulfonamide:

rapidly absorbed
UTI
systemic infection

A

Sulfisoxazole

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10
Q

What sulfonamide:

poorly absorbed
irritable bowel disorder

A

Sulfasalazine

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11
Q

What are adverse effects of sulfonamides? (6)

A

crystalluria
hypersensitivity
GI disturbances
hemolytic disturbances
hyperbilirubinemia
N/V

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12
Q

What acts synergistically with sulfonamide?

A

trimethoprim, (Co-trimoxazole), 1/10

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13
Q

Trimethoprim is a broad spectrum antibiotic. True or false?

A

True

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14
Q

What is DOC:

Urinary tract infections. Acute, chronic, recurrent
Chronic bacterial prostatitis
Pneumocystis carinii pneumonia in AIDS patients

A

Trimethoprim

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15
Q

What class of antibiotic is a DNA gyrase (topoisomerase II) inhibitor?

A

Quinolones

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16
Q

What are the fluoroquinolines? (4)

A

Cipro

Floxin

Levofloxacin

Gatifoxacin

17
Q

Fluoroquinolones have an after-drug effect. True or false?

A

True

18
Q

Fluoroquinolines are most active again most aerobic Gram + bacteria. True or false?

A

False, Gram -

19
Q

Are the fluoroquinolones well tolerated and safe for pregnant women or children < 18 y/o?

A

Yes, well tolerated but not safe for preggo and <18 y/o.

20
Q

What are drug interactions of quinolones? (4)

A

P450 inhibition, potentiate theophylline toxicity

Caffeine

NSAIDs

Divalent, trivalent cations

21
Q

What fluoroquinolines inhibit P450? (2)

A

Cipro

ofloxacin (Floxin)

22
Q

What fluoroquinoline is also known as inhalational anthrax?

A

Cipro

Pharmacology Exam 4 (12 decks)

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