Exam 2009 Flashcards
Molecular targets for antibiotic agents include:
a) bacterial cell wall synthesis
b) bacterial protein synthesis components
c) bacterial metabolism of essential nutrients
d) all of the above
d) all of the above
Common mechanisms by which bacteria develop resistance to beta-lactam antibiotic
a) spontaneous mutations in the target proteins resulting in loss of drug binding
b) endogenous enzymes that inactivate the drug
c) both A and B
D) neither A nor B
c) both A and B
a semi-synthetic, broad spectrum beta-lactam antibiotic is
a) pencillin G
b) imipenem/cilastatin (premaxin)
c) amoxicillin/clavulantate (augmentin)
d) aztreonam (azactam)
c) amoxicillin/clavulantate (augmentin)
this antibiotic agent is used most commonly as a surgical prophylaxis to prevent post-operative infections
a) bacitracin
b) cefazolin (ancef)
c) azithromycin (zithromax)
d) minocycline (minocin)
b) cefazolin (ancef)
this bacterial agent was developed recently to treat bacterial strains that are resistant to most established antibiotics
a) tetracycline (achromycin V)
b) daptomycin (cidecin)
c) erythromycin (ilotycin)
d) chloramphenicol
b) daptomycin (cidecin)
the “fractional cell kill’ or “log kill” hypothesis of cancer chemotherapy refers to the concept that
a) a set drug concentration given for a defined period of time will kill a constant % of cells, independent of the absolute number of cells
b) chemotherapy theoretically never reduces the tumor cell population to zero.
c) both A and B are correct
d) neither A nor B are correct
c) both A and B are correct
antimicrotubule drugs are effective chemotherapy agents because they
a) function as analogs of folic acid
b) interfere with tubulin polymerization or microtuble depolymerization
c) are metabolized into active alkyl groups that cross link DNA
d) produce free radicals that cause DNA damage
b) interfere with tubulin polymerization or microtuble depolymerization
the term “targeted therapy”’ refers to a drug that is
a) an antibody or small molecule kinase inhibitor against a specific protein thought to be important for cancer cell growth or survival,
b) able to intercalate into DNA and block DNA replication
c) an analog of a nucleotide
d) a competitive inhibitor of dihydrofolate reductase
a) an antibody or small molecule kinase inhibitor against a specific protein thought to be important for cancer cell growth or survival,
____ is a highly soluble sulfonamide with a short half-life used for systemic bacterial infection (i.e. UTI)
a) co-trimoxazole (bactrim)
b) sulfasalazine (azulfidine)
c) ciprofloxacin
d) sulfisoxazole (gantrisin)
e) trimethoprim
d) sulfisoxazole (gantrisin)
____ is a combination of trimethoprim and sulfamethoxazole
a) co-trimoxazole (bactrim)
b) sulfasalazine (azulfidine)
c) ciprofloxacin
d) sulfisoxazole (gantrisin)
e) trimethoprim
a) co-trimoxazole (bactrim)
_____ is a DNA gyrase inhibitor used in the treatment of inhalational anthrax infection
a) co-trimoxazole (bactrim)
b) sulfasalazine (azulfidine)
c) ciprofloxacin
d) sulfisoxazole (gantrisin)
e) trimethoprim
c) ciprofloxacin
____ is a poorly absorbed sulfonamide used for the treatment of inflammatory bowel disorders
a) co-trimoxazole (bactrim)
b) sulfasalazine (azulfidine)
c) ciprofloxacin
d) sulfisoxazole (gantrisin)
e) trimethoprim
b) sulfasalazine (azulfidine)
_______ is used for the treatment of infections by influenza A virus
a) acyclovir (zovirax)
b) amphotericin B (amphocin)
c) intraconazole (sporanox)
d) caspofungin (cancidas)
e) amantadine (symmetrel)
e) amantadine (symmetrel)
___ is glucan synthase inhibitor that blocks fungal cell wall biosynthesis
a) acyclovir (zovirax)
b) amphotericin B (amphocin)
c) intraconazole (sporanox)
d) caspofungin (cancidas)
e) amantadine (symmetrel)
d) caspofungin (cancidas)
_______ targets ergosterol in the fungal cell membrane, leading to channel formation and the loss of intracellular constituents.
a) acyclovir (zovirax)
b) amphotericin B (amphocin)
c) intraconazole (sporanox)
d) caspofungin (cancidas)
e) amantadine (symmetrel)
b) amphotericin B (amphocin)
