Aminogycosides & Anti-TB Drugs Flashcards

1
Q

What drugs are rapidly bacteriocidal?

A

aminoglycosides

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2
Q

What is an aminoglycoside is most commonly used?

A

Gentomyacin

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3
Q

What antibiotic:

primarily used in aerobic, Gram - bacteria

A

Aminoglycosides

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4
Q

What are the side effects of aminoglycosides? (2)

A

Ototoxicity, irreversible

Nephrotoxicity, reversible

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5
Q

What 2 antibiotics should never be mixed in the same vial?

A

Aminoglycosides and PCNs!

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6
Q

What are some aminoglycosides? (5)

A

Gentamicin

Streptomycin

Amikacin

Neomycin

Kanamycin

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7
Q

What aminoglycoside:

1st discovered
Primarily used to treat multidrug resistant TB
Very toxic
Treats bacterial endocarditis

A

Streptomycin

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8
Q

What aminoglycoside:

Topical only for infections of skin, mucous

A

Neomycin

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9
Q

What aminoglycoside:

Preferred for P. aeruginosa infections

A

Gentomycin

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10
Q

What aminoglycoside:

Effective in infections with organisms resistant to gentamicin

Semi-synthetic

Most expensive

A

Amikacin

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11
Q

Mycobacterium tuberculosis, the microorganism that causes TBt survives within _________.

A

macrophages

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12
Q

What anti-TB drug inhibits mycolic acid?

A

Isoniazid

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13
Q

What is the DOC (in combination with another drug) for TB?

A

Isoniazid

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14
Q

What anti-TB drug:

Broad spectrum
Mostly Gram +
Inhibits RNA synthesis (RNA polymerase)

A

Rifampin

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15
Q

What 2 anti-TB drugs are the most highly effective combinations?

A

Isoniazid

Rifampin

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16
Q

What anti-TB:

causes induction of hepatic metabolizing enzymes thus enhancing metabolism of many other drugs, such as warfarin,glucocorticoids, oral contraceptives

A

Rifampin

17
Q

What anti-TB drug:

**Inhibits mycobacterial arabinosyl transferases **

A

Ethambutol (Myambutol®)

18
Q

Combination therapy of multidrugs for TB is mandatory. True or false?

A

True