SUD Flashcards
how does disulfuram work
blocks aldehyde dehydrogenase which causes build up acetalydehyde
what order elimination does alcohol follow
zero order
when should you avoid using naltrexone
hepatitis or liver failure
when should you avoid using acamprosate
renal disease (but not in kidney stones)
which two AD are effective in smoking cessation
- bupropion 2. nortriptyline
which two smoking cessation meds have black box SI warnings
- bupropion. 2. vareniciline
most associated physical finding with PCP intoxication
nystagmus
how many drinks can a woman have in a week
10 servings with no more than 2 in one sitting
how many drinks can a man have in a week
15 servings with no more than 3 in one sitting
pt with vertical or horizontal nystagmus, two most likely illicit drugs did he take
PCP or inhalants
what is the period of time to classify someone as being in early remission from etoh
3 to <12 mo
what is the period of time to classify someone as being in sustained remission from etoh
12 mo+
which enzyme does disulfiram block?
aldehyde dehydrogenase
which lab test is the most sensitive indicator of alcoholism
CDT
facial dyskinesias indicate which illicit drug use
stimulants (amphetamines) or L-dopa (but with this they would have a clear sensorium)
only efficacious tx for cocaine d/o
relapse preventions
neurotransmitter involved in opioid withdrawal
norepienphrine
cocaine’s MOA
Da reuptake inhibitor
best long acting opioid med in pregnant women abusing opioids
methadone
what is the weekly drinking limit for women
10/week
what is the weekly drinking limit for men
15/week
during which period in cocaine w/d does one experience least cravings
hyperphagia (late crash period)
MOA of amphetamines
stimulates DA release
what is the least lethal route of cocaine intake?
inhaling
generally in illicit drug use does one become hyper or hyporeflexive
hypo
how long do cocaine metabolites last in the body
96h
best tx for alcoholic hallucinosis
benzos
during alcoholic hallucinosis is there a clear sensorium
yes
which two meds may help with cocaine w/d
- bromocriptine. 2. amtadine (both dopaminergic)
what is the timeline of alcohol w/d
- w/z sz peak at 1 day 2. hallucinosis peaks at 2 days 3. DT peak at 4-5 days after last drink
which neurotransmitter is involved in etoh w/d
glutamate
which receptor does glutamate inhibit
NMDA
MOA of varenicicline
partial agonist of A4B2 nicotinic receptor
severe depression follows use of which drug
MDMA (ecstasy)
which neurotransmitter is responsible for relapse
glutamate triggers reward system
which pathway is thought to be responsible for addiction
release fo DA from the VTA to the nucleus accumbens.
according to the ECA study what are the top two most prevalent disorders
- SUD 2. Anxiety
what is a “field” study
something done to see if it can be used practically
