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THE EXAM > SUD > Flashcards

SUD Flashcards

1
Q

how does disulfuram work

A

blocks aldehyde dehydrogenase which causes build up acetalydehyde

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2
Q

what order elimination does alcohol follow

A

zero order

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3
Q

when should you avoid using naltrexone

A

hepatitis or liver failure

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4
Q

when should you avoid using acamprosate

A

renal disease (but not in kidney stones)

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5
Q

which two AD are effective in smoking cessation

A
  1. bupropion 2. nortriptyline
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6
Q

which two smoking cessation meds have black box SI warnings

A
  1. bupropion. 2. vareniciline
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7
Q

most associated physical finding with PCP intoxication

A

nystagmus

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8
Q

how many drinks can a woman have in a week

A

10 servings with no more than 2 in one sitting

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9
Q

how many drinks can a man have in a week

A

15 servings with no more than 3 in one sitting

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10
Q

pt with vertical or horizontal nystagmus, two most likely illicit drugs did he take

A

PCP or inhalants

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11
Q

what is the period of time to classify someone as being in early remission from etoh

A

3 to <12 mo

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12
Q

what is the period of time to classify someone as being in sustained remission from etoh

A

12 mo+

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13
Q

which enzyme does disulfiram block?

A

aldehyde dehydrogenase

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14
Q

which lab test is the most sensitive indicator of alcoholism

A

CDT

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15
Q

facial dyskinesias indicate which illicit drug use

A

stimulants (amphetamines) or L-dopa (but with this they would have a clear sensorium)

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16
Q

only efficacious tx for cocaine d/o

A

relapse preventions

17
Q

neurotransmitter involved in opioid withdrawal

A

norepienphrine

18
Q

cocaine’s MOA

A

Da reuptake inhibitor

19
Q

best long acting opioid med in pregnant women abusing opioids

A

methadone

20
Q

what is the weekly drinking limit for women

A

10/week

21
Q

what is the weekly drinking limit for men

A

15/week

22
Q

during which period in cocaine w/d does one experience least cravings

A

hyperphagia (late crash period)

23
Q

MOA of amphetamines

A

stimulates DA release

24
Q

what is the least lethal route of cocaine intake?

A

inhaling

25
Q

generally in illicit drug use does one become hyper or hyporeflexive

A

hypo

26
Q

how long do cocaine metabolites last in the body

A

96h

27
Q

best tx for alcoholic hallucinosis

A

benzos

28
Q

during alcoholic hallucinosis is there a clear sensorium

A

yes

29
Q

which two meds may help with cocaine w/d

A
  1. bromocriptine. 2. amtadine (both dopaminergic)
30
Q

what is the timeline of alcohol w/d

A
  1. w/z sz peak at 1 day 2. hallucinosis peaks at 2 days 3. DT peak at 4-5 days after last drink
31
Q

which neurotransmitter is involved in etoh w/d

A

glutamate

32
Q

which receptor does glutamate inhibit

A

NMDA

33
Q

MOA of varenicicline

A

partial agonist of A4B2 nicotinic receptor

34
Q

severe depression follows use of which drug

A

MDMA (ecstasy)

35
Q

which neurotransmitter is responsible for relapse

A

glutamate triggers reward system

36
Q

which pathway is thought to be responsible for addiction

A

release fo DA from the VTA to the nucleus accumbens.

37
Q

according to the ECA study what are the top two most prevalent disorders

A
  1. SUD 2. Anxiety
38
Q

what is a “field” study

A

something done to see if it can be used practically

THE EXAM (19 decks)

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