substance abuse pt 2 Flashcards
MC preventable cause of mortality
smoking
smoking increases the risks of?
ASHD, COPD, stroke, cancer (especially lung)
who are the at-risk populations of smoking?
Divorced/widowed, lower income or education, AI/AN or multiracial, LGBTQ
risk factors for smoking?
- Relationships -
- Parents, friends, housemate who smokes
- Strained relationship with parent - Psychiatric -
- Low self-esteem
- Comorbid psychiatric disorders - Female - Preoccupation with weight and body image
- Male - Aggression and rebelliousness
other forms of tobacco?
-
Cigars/Pipes - typically not inhaled as deeply into lungs
- Slightly lower risk of lung cancer -
Hookahs - varying amounts of nicotine and toxins
- Vapor/smoke from burning product (such as tobacco) is passed through a water chamber before being inhaled
- Still linked to cancer, COPD -
Smokeless Tobacco - varying amounts of toxins
- 3% of US adults -
E-Cigarettes/Vaping - aerosolized nicotine - similar vapor to cigarettes, fewer traditional toxins
- Significantly increasing rates of use among adults and children/adolescents
who is the most likely to use smokeless tobacco?
white males of low socioeconomic status in southern US
Linked to nicotine addiction, cancer of oral cavity
what is EVALI?
acute lung injury associated specifically with the use of vaping products
Acute eosinophilic pneumonia reported after vape use
MOA of nicotine
stimulates nicotinic cholinergic receptors in the brain
Triggers dopamine release
Triggers epinephrine release
nicotine reaches the brain how fast?
15 sec; t½ about 1-2 hours
Some genetic variants - metabolize more slowly
what are the positive effects after nicotine intake
- Dopamine:
- Decreased anxiety
- Improved mood - Epinephrine:
- Increased alertness and memory
- Decreased appetite
- Improved problem solving skills
- Improved reaction time
due to upregulation of nicotinic (acetylcholine) receptors → develops rapidly
tolerance
as early as 2 hrs after last cigarette, peaks in first 72 hrs, fades gradually over 3-4 weeks
withdrawal
what happens when you receive less dopamine than before (when smoking)? epinephrine?
- Less dopamine - irritable, hostile, anxious, restlessness, cravings
- Less epinephrine - decreased HR, insomnia, increased appetite, weight gain
- Craving may persist for years even after withdrawal ends
what are the acute toxic effects from tobacco
Nausea, salivation, pallor
Tachycardia, poor concentration
Decreased REM sleep
harmful effects of smoking
- Increased all-cause mortality - die on average 10 years earlier
- Cancer
-↑ risk - head and neck, lung, gastric, pancreatic, renal, ovarian, bladder, cervical, penile, anal - Pulmonary
-↑ risk - COPD
- Worse clinical course for COPD, asthma, bronchiolitis - Periodontal
- ↑ risk - periodontal disease (gingivitis, periodontitis) - Immunologic
↑ risk - several types of infections
- TB, Pneumococcal pneumonia, meningococcal disease, Legionnaires
disease, influenza, common cold - Endocrine
-↑ risk - type 2 DM
- Nicotine causes impaired insulin sensitivity
- May worsen course of type 2 DM - Musculoskeletal
-↑ risk - osteoporosis
- Accelerates bone loss - increased risk of hip fractures in females - Reproductive
-↑ risk - pregnancy complications
- Spontaneous abortion, ectopic pregnancy, low birth weight, fetal harm
-↑ risk - premature menopause, erectile dysfunction, infertility - Gastrointestinal
-↑ risk - gastric and duodenal ulcers
- Slower healing of gastric and duodenal ulcers
- Increased failure rates of H. pylori treatment - Postoperative
↑ risk - delayed wound healing, pulmonary complications, admission
to ICU, post-operative infection
what is present in tobacco and most vapes, not nicotine replacement and is not usually picked up from secondhand smoke
Anabasine
what nicotine metabolite is in serum - 16 hrs, urine - several weeks and can pick up from secondhand smoke exposure
continine
routes for nicotine replacement therapy
transdermal patch, gum, lozenge, inhaler, nasal spray
Different absorption than cigarettes
what is the recommended combo for nicotine replacement therapy
long-acting (patch) and short-acting (oral)
T/F: E-cigarettes are not FDA approved for tobacco cessation
T
what nicotine replacement therapy has good patient compliance - simplest method
No chance to adjust nicotine dose - continuous
transdermal patch
what is the dosing for transdermal patch
- Apply one patch each morning to any non-hairy skin
- Rotate site of application and do not leave on overnight
- If >10 cigarettes/day: 21 mg x 6 wks, 14 mg x 2 wks, 7 mg x 2 wks
- If 10 or less cigarettes/day: 14 mg x 6 wks, 7 mg x 2 wks
SE of transdermal patch
skin irritation (most common), insomnia, vivid dreams
Will also see SE of nicotine administration
which nicotine replacement therapy diminishes rather than stops withdrawal
oral nicotine gum
4 mg of nicotine gum is for pt who smoke ?
25+ cigarettes per day
what must you avoid when chewing nicotine gum
Avoid acidic beverages before and during gum use
TMJ, poor dentition, dental appliances
SE of nicotine gum
N/V/D, HA, excess salivation, mouth irritation
what nicotine replacement therapy Does not need to be chewed and has most nicotine content
Oral Nicotine Lozenge
SE of nicotine lozenge
mouth irritation, N/V/D, palpitations, HA, insomnia
what nicotine replacement therapy is absorbed through oral mucosa, like lozenge and gum
Helps satisfy sensory and behavioral cravings
nicotine inhaler
SE of nicotine inhaler
oropharynx irritation, bronchospasm
who should avoid using nicotine inhalers?
reactive airway disease (asthma)
which nicotine therapy is absorbed through nasal mucosa - more rapid peak than oral? SE?
nicotine nasal spray
SE - nasal and throat irritation, sneezing, tearing
what nicotine replacement therapy is not available in the US
Nicotine Mouth Spray and Nicotine Sublingual
which tobacco tx blocks dopamine and norepinephrine reuptake (DNRI), antagonizes nicotinic cholinergic receptors
Bupropion (Wellbutrin, Zyban)
SE of bupropion
MC are insomnia, agitation, dry mouth, headache
Rarer - seizure (dose-dependent)
CI for bupropion
epilepsy; high seizure risk; hx of anorexia or bulimia
partial agonist of nicotinic cholinergic receptors
Partial stimulation of receptor to decrease withdrawal
Blocks nicotine from binding to receptor, interfering with “reward”
Varenicline (Chantix)
SE of Varenicline (Chantix)
-
MC vivid dreams, nausea, insomnia, syncope
- When first released - concern over neuropsychiatric SE (mood, behavior, suicidal thoughts)
- Not as common as once thought - FDA has removed black box warning
- Potential adverse events in CV disease (controversial - not as common as once thought)
CI for Varenicline (Chantix)
hypersensitivity or skin reactions to rx
antibodies bind nicotine and stop it from crossing the blood-brain barrier
Blocks nicotine from binding to CNS receptor, interfering with “reward”
Nicotine Vaccine
several ongoing trials, but so far inadequate antibody responses or no improvement over placebo therapy
nonpharmacologic tx for tobacco
- Behavioral counseling (including 5 A’s)
- Acupuncture (questionable benefit)
- Financial incentives